Aplaviroc hydrochloride

Name: Aplaviroc hydrochloride
Brand: TargetMol
SKU: T26642
Rating: 4.5 (1 reviews)

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Catalog No. T26642Cas No. 461023-63-2

Alias GW873140A, GW-873140, GW873140, Aplaviroc HCl, AK-602, AK602, AK 602

Aplaviroc is a human cellular CC chemokine receptor 5 (CCR5) entry inhibitor. Aplaviroc binds specifically to CCR5 and demonstrates potent anti-human immunodeficiency virus activity in vitro in the subnanomolar range. In vitro studies show that aplaviroc selectively inhibits the binding of a particular monoclonal antibody, 45531, to CCR5.

Aplaviroc hydrochloride

😃Good

Catalog No. T26642Alias GW873140A, GW-873140, GW873140, Aplaviroc HCl, AK-602, AK602, AK 602Cas No. 461023-63-2

Pack Size	Price	Availability
25 mg	$2,420	10-14 weeks
50 mg	$3,260	10-14 weeks
100 mg	$4,380	10-14 weeks

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Product Introduction

Bioactivity

Description	Aplaviroc is a human cellular CC chemokine receptor 5 (CCR5) entry inhibitor. Aplaviroc binds specifically to CCR5 and demonstrates potent anti-human immunodeficiency virus activity in vitro in the subnanomolar range. In vitro studies show that aplaviroc selectively inhibits the binding of a particular monoclonal antibody, 45531, to CCR5.
Targets&IC50	HIV-1 (JRFL):0.1 nM (IC50), HIV-1 (MOKW):0.2 nM (IC50), HIV-1 (Ba-L):0.4 nM (IC50)
Synonyms	GW873140A, GW-873140, GW873140, Aplaviroc HCl, AK-602, AK602, AK 602

Chemical Properties

Molecular Weight	614.17
Formula	C₃₃H₄₄ClN₃O₆
Cas No.	461023-63-2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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