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Org41841

Name: Org41841
Brand: TargetMol
SKU: T16403
Price: 199 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16403Cas No. 301847-37-0

Alias Org-41841

Org41841 is an agonist of luteinising hormone/chorionic gonadotropin receptor and thyroid stimulating hormone receptor (EC50s: 0.2 and 7.7 μM, respectively) and can be used to study hyperthyroidism.

Org41841

🥰Excellent

Purity: 99.92%

Catalog No. T16403Alias Org-41841Cas No. 301847-37-0

Org41841 is an agonist of luteinising hormone/chorionic gonadotropin receptor and thyroid stimulating hormone receptor (EC50s: 0.2 and 7.7 μM, respectively) and can be used to study hyperthyroidism.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$199	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.92%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Org41841 is an agonist of luteinising hormone/chorionic gonadotropin receptor and thyroid stimulating hormone receptor (EC50s: 0.2 and 7.7 μM, respectively) and can be used to study hyperthyroidism.
Targets&IC50	LHCGR:0.2 μM （EC50）, TSHR:7.7 μM（EC50）
In vitro	org41841 is a partial agonist of TSHR, but its potency is lower than LHCGR[1].
Synonyms	Org-41841

Chemical Properties

Molecular Weight	402.53
Formula	C₁₉H₂₂N₄O₂S₂
Cas No.	301847-37-0
Smiles	COc1cccc(c1)-c1nc(SC)nc2sc(C(=O)NC(C)(C)C)c(N)c12
Relative Density.	1.33 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (198.51 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4843 mL	12.4214 mL	24.8429 mL	124.2143 mL
5 mM	0.4969 mL	2.4843 mL	4.9686 mL	24.8429 mL
10 mM	0.2484 mL	1.2421 mL	2.4843 mL	12.4214 mL
20 mM	0.1242 mL	0.6211 mL	1.2421 mL	6.2107 mL
50 mM	0.0497 mL	0.2484 mL	0.4969 mL	2.4843 mL
100 mM	0.0248 mL	0.1242 mL	0.2484 mL	1.2421 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc