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XE 991 dihydrochloride

Name: XE 991 dihydrochloride
Brand: TargetMol
SKU: T17262
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T17262Cas No. 122955-13-9

XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker. XE 991 dihydrochloride potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current (IC50s: 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively).

XE 991 dihydrochloride

🥰Excellent

Purity: 98.68%

Catalog No. T17262Cas No. 122955-13-9

Pack Size	Price	Availability
1 mg	$41	In Stock
5 mg	$97	In Stock
10 mg	$155	In Stock
25 mg	$296	In Stock
50 mg	$455	In Stock
100 mg	$683	In Stock
200 mg	$949	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Batch Information

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Purity:98.68%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker. XE 991 dihydrochloride potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current (IC50s: 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively).
Targets&IC50	M-current:0.98 μM, Kv7.2/Kv7.3 channel:0.6 μM, Kv7.2 channel:0.71 μM, Kv7.1 channel:0.75 μM

Chemical Properties

Molecular Weight	449.37
Formula	C₂₆H₂₂Cl₂N₂O
Cas No.	122955-13-9
Smiles	Cl.Cl.O=C1c2ccccc2C(Cc2ccncc2)(Cc2ccncc2)c2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 12 mg/mL (26.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2253 mL	11.1267 mL	22.2534 mL	111.2669 mL
5 mM	0.4451 mL	2.2253 mL	4.4507 mL	22.2534 mL
10 mM	0.2225 mL	1.1127 mL	2.2253 mL	11.1267 mL
20 mM	0.1113 mL	0.5563 mL	1.1127 mL	5.5633 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc