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Isoxsuprine hydrochloride

Name: Isoxsuprine hydrochloride
Brand: TargetMol
SKU: T0324
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0324Cas No. 579-56-6

Alias Isolait, Duvadilan

Isoxsuprine hydrochloride (Isolait) is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle.

Isoxsuprine hydrochloride

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Purity: 99.38%

Catalog No. T0324Alias Isolait, DuvadilanCas No. 579-56-6

Isoxsuprine hydrochloride (Isolait) is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$47	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$33	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.38%

Appearance:Solid

Color:White

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Isoxsuprine hydrochloride AI Summary

Isoxsuprine hydrochloride exhibits a diverse range of bioactivities. It demonstrates significant uterine relaxant activity by inhibiting oxytocin-induced contractions in isolated rat uterus preparations with an IC50 of 9150.0 nM and also delays the onset of labor in rats at a 10 mg dosage. The compound affects cAMP release and heart rate in rats at varying dosages. In terms of signaling pathways, Isoxsuprine hydrochloride acts as both an agonist and antagonist for the Hypoxia Response Element Signaling Pathway at 125.9 nM, inhibits the ERK signaling pathway at 39810.7 nM, and targets T. brucei phosphofructokinase at 952.8 nM. Additionally, it shows inhibitory effects on HP1-beta Chromodomain interactions, the malarial parasite plastid, DNA re-replication in SW480 colon adenocarcinoma cells, alpha-syn, and Ebola Virus entry. For antiviral activity, the compound exhibits limited inhibition of cell viability in Vero E6 cells infected with SARS-CoV-2 (-0.02068%) but shows 16.99% inhibition of SARS-CoV-2-induced cytotoxicity in Caco-2 cells at 10 µM after 48 hours. Furthermore, it inhibits the SARS-CoV-2 3CL-Pro protease with 31.28% efficacy at 20 µM. Isoxsuprine hydrochloride also inhibits sodium fluorescein uptake in OATP1B1-transfected (38.44% at 10 µM) and OATP1B3-transfected CHO cells (77.52% at 10 µM). Its antimicrobial activities are modest, with varying inhibition percentages against Candida albicans, Cryptococcus neoformans, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and MRSA. Finally, it exhibits inhibitory activity against human HDAC6 in an enzymatic assay with significant variance depending on the substrate, showing -62.97% inhibition with a commercial peptide substrate but only 0.83% with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Isoxsuprine hydrochloride (Isolait) is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle.
Targets&IC50	β-adrenoceptor (myometrial):13.65 μΜ (Ki), β-adrenoceptor (placcntal):3.48 μΜ (Ki)
Synonyms	Isolait, Duvadilan

Chemical Properties

Molecular Weight	337.84
Formula	C₁₈H₂₄ClNO₃
Cas No.	579-56-6
Smiles	Cl.CC(COc1ccccc1)NC(C)C(O)c1ccc(O)cc1
Relative Density.	1.146g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 11.8 mM, Sonication is recommended.

DMSO: 45 mg/mL (133.2 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9600 mL	14.7999 mL	29.5998 mL	147.9991 mL
5 mM	0.5920 mL	2.9600 mL	5.9200 mL	29.5998 mL
10 mM	0.2960 mL	1.4800 mL	2.9600 mL	14.7999 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1480 mL	0.7400 mL	1.4800 mL	7.4000 mL
50 mM	0.0592 mL	0.2960 mL	0.5920 mL	2.9600 mL
100 mM	0.0296 mL	0.1480 mL	0.2960 mL	1.4800 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc