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TUG-770

Name: TUG-770
Brand: TargetMol
SKU: TQ0241
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0241Cas No. 1402601-82-4

Alias TUG770, TUG 770

TUG-770 is a GPR40/FFA1 agonist with potential anti-inflammatory activity.TUG-770 can be used to study type 2 diabetes, dementia, and Alzheimer's disease.

TUG-770

😃Good

Purity: 97.6%

Catalog No. TQ0241Alias TUG770, TUG 770Cas No. 1402601-82-4

TUG-770 is a GPR40/FFA1 agonist with potential anti-inflammatory activity.TUG-770 can be used to study type 2 diabetes, dementia, and Alzheimer's disease.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$58	-	In Stock
5 mg	$139	-	In Stock
10 mg	$222	5 days	5 days
25 mg	$429	7-10 days	7-10 days
50 mg	$687	7-10 days	7-10 days
100 mg	$987	7-10 days	7-10 days
500 mg	$1,980	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$213	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.6%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	TUG-770 is a GPR40/FFA1 agonist with potential anti-inflammatory activity.TUG-770 can be used to study type 2 diabetes, dementia, and Alzheimer's disease.
Targets&IC50	FFA1/GPR40 (human):6 nM (EC50)
In vitro	TUG-770 shows good stability towards human liver microsomes (HLM) and demonstrates good permeability in the Caco-2 cell assay[1].
In vivo	In C57BL/6 male mice (5-6 weeks of age) fed a 60% fat diet D12492, TUG-770 (20 mg/kg; oral administration; daily; for 28 days) significantly improved glucose tolerance[1].
Synonyms	TUG770, TUG 770

Chemical Properties

Molecular Weight	307.32
Formula	C₁₉H₁₄FNO₂
Cas No.	1402601-82-4
Smiles	OC(=O)CCc1ccc(cc1F)C#Cc1ccccc1CC#N
Relative Density.	1.28 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble

DMSO: 100 mg/mL (325.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (10.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2539 mL	16.2697 mL	32.5394 mL	162.6969 mL
5 mM	0.6508 mL	3.2539 mL	6.5079 mL	32.5394 mL
10 mM	0.3254 mL	1.6270 mL	3.2539 mL	16.2697 mL
20 mM	0.1627 mL	0.8135 mL	1.6270 mL	8.1348 mL
50 mM	0.0651 mL	0.3254 mL	0.6508 mL	3.2539 mL
100 mM	0.0325 mL	0.1627 mL	0.3254 mL	1.6270 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc