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FR183998 free base

Name: FR183998 free base
Brand: TargetMol
SKU: T11319
Price: 105 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11319Cas No. 239440-20-1

FR183998 free base is an inhibitor of Na+/Ca2+ Exchanger.

FR183998 free base

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Purity: 99.61%

Catalog No. T11319Cas No. 239440-20-1

FR183998 free base is an inhibitor of Na+/Ca2+ Exchanger.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$105	In Stock	In Stock
5 mg	$259	In Stock	In Stock
10 mg	$397	In Stock	In Stock
25 mg	$728	In Stock	In Stock
50 mg	$977	In Stock	In Stock
100 mg	$1,320	In Stock	In Stock
200 mg	$1,780	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.61%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	FR183998 free base is an inhibitor of Na+/Ca2+ Exchanger.
Targets&IC50	Na+, H+ exchange (human platelet):3.1 nM , Na+, H+ exchange (rat lymphocytes):0.3 nM , Na+, H+ exchange (rat platelet):6.5 nM
In vitro	FR183998 free base has potent inhibitory effects on Na+/H+ exchanger in rat lymphocytes, rat platelets, and human platelets with IC50s of 0.3 nM, 6.5 nM, and 3.1 nM, respectively[1].
In vivo	Administered intravenously at 1 mg/kg, FR183998 free base diminishes the serum elevation of alanine transaminase, aspartate transaminase, and lactate dehydrogenase caused by hepatic ischemia/reperfusion (I/R), while also preventing hepatic necrosis, apoptosis, and neutrophil infiltration. It inhibits the I/R-triggered activation of NF-κB, downregulates iNOS induction, and curbs nitric oxide production, in addition to reducing the liver's iNOS gene antisense transcript expression in hepatic I/R rats. At dosages of 0.1 and 1.0 mg/kg via intravenous injection, FR183998 free base does not alter hemodynamic parameters, mean blood pressure, or heart rate in conscious rats. Both pre- and post-treatment with FR183998 free base, in doses ranging from 0.01 to 0.10 mg/kg intravenously, dose-dependently mitigates reperfusion-induced ventricular fibrillation and mortality in anesthetized rats, showing ED50 values against ventricular fibrillation of 0.015 mg/kg and 0.070 mg/kg, respectively. Moreover, it significantly reduces myocardial infarct sizes and suppresses arrhythmias in anesthetized rats.

Chemical Properties

Molecular Weight	428.34
Formula	C₁₇H₁₉Cl₂N₅O₂S
Cas No.	239440-20-1
Smiles	CN(C)CCNC(=O)c1cc(cc(c1)-c1cc(Cl)sc1Cl)C(=O)NC(N)=N
Relative Density.	1.48 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (466.92 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3346 mL	11.6730 mL	23.3459 mL	116.7297 mL
5 mM	0.4669 mL	2.3346 mL	4.6692 mL	23.3459 mL
10 mM	0.2335 mL	1.1673 mL	2.3346 mL	11.6730 mL
20 mM	0.1167 mL	0.5836 mL	1.1673 mL	5.8365 mL
50 mM	0.0467 mL	0.2335 mL	0.4669 mL	2.3346 mL
100 mM	0.0233 mL	0.1167 mL	0.2335 mL	1.1673 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc