Shopping Cart
- Remove All
Your shopping cart is currently empty
Anti-Phospho-RAF1 (S621) Antibody (6G681)
😃Good
Catalog No. TMAC-03259
Anti-Phospho-RAF1 (S621) Antibody (6G681) is a Rabbit antibody targeting Phospho-RAF1 (S621). Anti-Phospho-RAF1 (S621) Antibody (6G681) can be used in WB.
Anti-Phospho-RAF1 (S621) Antibody (6G681)
Anti-Phospho-RAF1 (S621) Antibody (6G681)
😃Good
Catalog No. TMAC-03259
Anti-Phospho-RAF1 (S621) Antibody (6G681) is a Rabbit antibody targeting Phospho-RAF1 (S621). Anti-Phospho-RAF1 (S621) Antibody (6G681) can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $296 | 7-10 days | |
| 100 μL | $497 | 7-10 days |
Add to Cart
Add to Quotation
Bulk & Custom
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
View MoreResource Download
Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Phospho-RAF1 (S621) Antibody (6G681) is a Rabbit antibody targeting Phospho-RAF1 (S621). Anti-Phospho-RAF1 (S621) Antibody (6G681) can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:1000-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Raf-1 is a ubiquitously expressed cytoplasmic protein with intrinsic serine/threonine kinase activity. Raf-1, or c-Raf, is the cellular homolog of v-Raf, the product of the transforming gene of the 3611 strain of murine sarcoma virus. The unregulated kinase activity of the v-Raf protein is associated with cellular transformation and mitogenesis. Raf-1 is normally suppressed by its regulatory N-terminal domain. Raf-1 is activated in response to a variety of tyrosine kinase receptors as well as in response to pp60v-Src expression. Specifically, Raf-1 is phosphorylated in the catalytic domain at Ser 338 and, to a lesser extent, Ser 339. This phosphorylation requires the co-activation of PI 3-kinase and the Ras signaling pathway. Raf-1 is also phosphorylated on Tyr 340 and 341, which induces the phosphorylation of MEK. Phosphorylation of Ser 621 is essential for the catalytic activity of Raf-1 and downregulation by c-AMP-dependent protein kinase A (PKA). PKA also phosphorylates Raf-1 on Ser 43 and Ser 259. PKA phosphorylation of Ser 259 inhibits Raf-1 and decreases the phosphorylation necessary for Raf-1 activation at Ser 338. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | A synthesized phosphopeptide: human Raf1 around the phosphorylation site of Ser621 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Theoretical: 73 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Calculator
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Anti-Phospho-RAF1 (S621) Antibody (6G681) | purchase Anti-Phospho-RAF1 (S621) Antibody (6G681) | Anti-Phospho-RAF1 (S621) Antibody (6G681) cost | order Anti-Phospho-RAF1 (S621) Antibody (6G681) | Anti-Phospho-RAF1 (S621) Antibody (6G681) molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.