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Anti-Phospho-RAF1 (S621) Antibody (6G681)

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Catalog No. TMAC-03259

Anti-Phospho-RAF1 (S621) Antibody (6G681) is a Rabbit antibody targeting Phospho-RAF1 (S621). Anti-Phospho-RAF1 (S621) Antibody (6G681) can be used in WB.

Anti-Phospho-RAF1 (S621) Antibody (6G681)

Anti-Phospho-RAF1 (S621) Antibody (6G681)

😃Good
Catalog No. TMAC-03259
Anti-Phospho-RAF1 (S621) Antibody (6G681) is a Rabbit antibody targeting Phospho-RAF1 (S621). Anti-Phospho-RAF1 (S621) Antibody (6G681) can be used in WB.
Pack SizePriceAvailabilityQuantity
50 μL$2967-10 days
100 μL$4977-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-RAF1 (S621) Antibody (6G681) is a Rabbit antibody targeting Phospho-RAF1 (S621). Anti-Phospho-RAF1 (S621) Antibody (6G681) can be used in WB.
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1:1000-2000
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundRaf-1 is a ubiquitously expressed cytoplasmic protein with intrinsic serine/threonine kinase activity. Raf-1, or c-Raf, is the cellular homolog of v-Raf, the product of the transforming gene of the 3611 strain of murine sarcoma virus. The unregulated kinase activity of the v-Raf protein is associated with cellular transformation and mitogenesis. Raf-1 is normally suppressed by its regulatory N-terminal domain. Raf-1 is activated in response to a variety of tyrosine kinase receptors as well as in response to pp60v-Src expression. Specifically, Raf-1 is phosphorylated in the catalytic domain at Ser 338 and, to a lesser extent, Ser 339. This phosphorylation requires the co-activation of PI 3-kinase and the Ras signaling pathway. Raf-1 is also phosphorylated on Tyr 340 and 341, which induces the phosphorylation of MEK. Phosphorylation of Ser 621 is essential for the catalytic activity of Raf-1 and downregulation by c-AMP-dependent protein kinase A (PKA). PKA also phosphorylates Raf-1 on Ser 43 and Ser 259. PKA phosphorylation of Ser 259 inhibits Raf-1 and decreases the phosphorylation necessary for Raf-1 activation at Ser 338.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
A synthesized phosphopeptide: human Raf1 around the phosphorylation site of Ser621
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 73 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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