Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Compound G-5b, an estrogen receptor modulator 10, functions as an estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM). It has the capability to induce apoptosis and block cells at the G1/G0 phase, making it applicable in cancer research [1].
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Description | Compound G-5b, an estrogen receptor modulator 10, functions as an estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM). It has the capability to induce apoptosis and block cells at the G1/G0 phase, making it applicable in cancer research [1]. |
In vitro | The estrogen receptor modulator 10, at concentrations of 20-100 nM applied for 2-48 hours, significantly suppresses the activity of the estrogen receptor (ER) in T47D cells in a dose-dependent manner. In MCF-7 cells, it elicits a delayed reduction in the degradation level of cellular ER compared to T47D cells [1]. |
In vivo | Estrogen receptor modulator 10 (30 mg/kg, intramuscular (i.m.) injection, single dose) exhibited favorable pharmacokinetic properties in female Sprague-Dawley rats [1]. |
Molecular Weight | 728.71 |
Formula | C32H37F9N4O3S |
CAS No. | 2991504-90-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Estrogen receptor modulator 10 2991504-90-4 Endocrinology/Hormones Estrogen Receptor/ERR inhibitor inhibit