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Anti-PHD2 Antibody (2X707)

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Catalog No. TMAB-10262

Anti-PHD2 Antibody (2X707) is a Rabbit antibody targeting PHD2. Anti-PHD2 Antibody (2X707) can be used in WB,IP.

Anti-PHD2 Antibody (2X707)

Anti-PHD2 Antibody (2X707)

😃Good
Catalog No. TMAB-10262
Anti-PHD2 Antibody (2X707) is a Rabbit antibody targeting PHD2. Anti-PHD2 Antibody (2X707) can be used in WB,IP.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1517-10 days7-10 days
50 μL$2637-10 days7-10 days
100 μL$4727-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-PHD2 Antibody (2X707) is a Rabbit antibody targeting PHD2. Anti-PHD2 Antibody (2X707) can be used in WB,IP.
Ig Type
IgG
Clone
2X707
Reactivity
Human
Application
WB
IP
Recommended Dose
WB: 1:500-2000; IP: 1:20-50
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm. Nucleus.
Tissue SpecificityAccording to PubMed:11056053, widely expressed with highest levels in skeletal muscle and heart, moderate levels in pancreas, brain (dopaminergic neurons of adult and fetal substantia nigra) and kidney, and lower levels in lung and liver. According to PubMed:12351678 widely expressed with highest levels in brain, kidney and adrenal gland. Expressed in cardiac myocytes, aortic endothelial cells and coronary artery smooth muscle. According to PubMed:12788921; expressed in adult and fetal heart, brain, liver, lung, skeletal muscle and kidney. Also expressed in placenta. Highest levels in adult heart, brain, lung and liver and fetal brain, heart spleen and skeletal muscle.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Research BackgroundCellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
Antigen Details
Immunogen
A synthesized peptide: human PHD2
Antigen Species
Human
Gene Name
EGLN1
Gene ID
54583
Protein Name
Egl nine homolog 1
Uniprot ID
Q9GZT9
Chemical Properties
Molecular WeightTheoretical: 46 kDa. Actual: 46 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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