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Pyrazofurin (Synonyms: Pirazofurin)

Name: Pyrazofurin
Brand: TargetMol
SKU: T16690
Price: 132 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T16690 Copy Product Info

Purity: 98.17%

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Pyrazofurin is a pyrimidine nucleoside analogue that potently inhibits cell proliferation and DNA synthesis by targeting UMP synthase, while also acting as a highly sensitive orotate-phosphoribosyltransferase inhibitor with IC50 values ranging from 0.06 to 0.37 μM in Hep-2, HNSCC-14B, and HNSCC-14C cell lines, supporting the use of Pyrazofurin as a mechanistic probe for nucleotide biosynthesis inhibition and antiproliferative research.

Pyrazofurin

Copy Product Info

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Catalog No. T16690

Synonyms Pirazofurin

Cas No. 30868-30-5

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Pack Size	Price	USA Stock	Global Stock
1 mg	$132	-	In Stock
5 mg	$328	-	In Stock
10 mg	$463	-	In Stock
25 mg	$742	-	In Stock
50 mg	$987	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.17%

Appearance:Solid

Color:Yellow

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COA LCMS

Product Introduction

Bioactivity

Description	Pyrazofurin is a pyrimidine nucleoside analogue that potently inhibits cell proliferation and DNA synthesis by targeting UMP synthase, while also acting as a highly sensitive orotate-phosphoribosyltransferase inhibitor with IC50 values ranging from 0.06 to 0.37 μM in Hep-2, HNSCC-14B, and HNSCC-14C cell lines, supporting the use of Pyrazofurin as a mechanistic probe for nucleotide biosynthesis inhibition and antiproliferative research.
Targets&IC50	HEp-2 cells:0.06 - 0.37 μM
In vitro	In head and neck cancer cell lines, specifically HEP-2, UMSCC-14B, and UMSCC-14C, Pyrazofurin exhibited potent antiproliferative activity with IC50 values ranging from 0.06 to 0.37 μM[2]. In Vero cells, Pyrazofurin displayed broad-spectrum antiviral activity against Parainfluenza 3, Measles, Vaccinia, and Herpes Simplex Virus type 2 (HSV-2) with ED50 values ranging from 2.8 to 20 μM following a 72-hour incubation [3].
Synonyms	Pirazofurin

Chemical Properties

Molecular Weight	259.22
Formula	C₉H₁₃N₃O₆
Cas No.	30868-30-5
Smiles	O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)C=2C(O)=C(C(N)=O)NN2
Relative Density.	1.785 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 4 mg/mL (15.43 mM), Sonication is recommended.

DMSO: 40 mg/mL (154.31 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8577 mL	19.2886 mL	38.5773 mL	192.8864 mL
5 mM	0.7715 mL	3.8577 mL	7.7155 mL	38.5773 mL
10 mM	0.3858 mL	1.9289 mL	3.8577 mL	19.2886 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1929 mL	0.9644 mL	1.9289 mL	9.6443 mL
50 mM	0.0772 mL	0.3858 mL	0.7715 mL	3.8577 mL
100 mM	0.0386 mL	0.1929 mL	0.3858 mL	1.9289 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc