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Pyrazofurin
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Catalog No. T16690Cas No. 30868-30-5
Alias Pirazofurin
Pyrazofurin is a pyrimidine nucleoside analogue that potently inhibits cell proliferation and DNA synthesis by targeting UMP synthase, while also acting as a highly sensitive orotate-phosphoribosyltransferase inhibitor with IC50 values ranging from 0.06 to 0.37 μM in Hep-2, HNSCC-14B, and HNSCC-14C cell lines, supporting the use of Pyrazofurin as a mechanistic probe for nucleotide biosynthesis inhibition and antiproliferative research.
Pyrazofurin
😃Good
Purity: 98.17%
Catalog No. T16690Alias PirazofurinCas No. 30868-30-5
Pyrazofurin is a pyrimidine nucleoside analogue that potently inhibits cell proliferation and DNA synthesis by targeting UMP synthase, while also acting as a highly sensitive orotate-phosphoribosyltransferase inhibitor with IC50 values ranging from 0.06 to 0.37 μM in Hep-2, HNSCC-14B, and HNSCC-14C cell lines, supporting the use of Pyrazofurin as a mechanistic probe for nucleotide biosynthesis inhibition and antiproliferative research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $150 | - | In Stock | |
| 5 mg | $332 | - | In Stock | |
| 10 mg | $464 | - | In Stock | |
| 25 mg | $742 | - | In Stock | |
| 50 mg | $1,110 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.17%
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Pyrazofurin is a pyrimidine nucleoside analogue that potently inhibits cell proliferation and DNA synthesis by targeting UMP synthase, while also acting as a highly sensitive orotate-phosphoribosyltransferase inhibitor with IC50 values ranging from 0.06 to 0.37 μM in Hep-2, HNSCC-14B, and HNSCC-14C cell lines, supporting the use of Pyrazofurin as a mechanistic probe for nucleotide biosynthesis inhibition and antiproliferative research. |
| Targets&IC50 | HEp-2 cells:0.06 - 0.37 μM |
| In vitro | In head and neck cancer cell lines, specifically HEP-2, UMSCC-14B, and UMSCC-14C, Pyrazofurin exhibited potent antiproliferative activity with IC50 values ranging from 0.06 to 0.37 μM[2]. In Vero cells, Pyrazofurin displayed broad-spectrum antiviral activity against Parainfluenza 3, Measles, Vaccinia, and Herpes Simplex Virus type 2 (HSV-2) with ED50 values ranging from 2.8 to 20 μM following a 72-hour incubation [3]. |
| Synonyms | Pirazofurin |
| Molecular Weight | 259.22 |
| Formula | C9H13N3O6 |
| Cas No. | 30868-30-5 |
| Smiles | O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)C=2C(O)=C(C(N)=O)NN2 |
| Relative Density. | 1.785 g/cm3 (Predicted) |
| Color | Yellow |
| Appearance | Solid |
| Storage | keep away from moisture,store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 4 mg/mL (15.43 mM), Sonication is recommended. DMSO: 40 mg/mL (154.31 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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