Shopping Cart
Remove All
Your shopping cart is currently empty
CL 218872
Copy Product Info
🥰Excellent
Catalog No. T8572Cas No. 66548-69-4
CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.
CL 218872
Copy Product Info🥰Excellent
Purity: 99.92%
Catalog No. T8572Cas No. 66548-69-4
CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $35 | In Stock | In Stock | |
| 50 mg | $62 | In Stock | In Stock | |
| 100 mg | $103 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.92%
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
CL 218872 AI Summary
CL 218872 exhibits significant bioactivity across various systems, predominantly influencing GABAergic neurotransmission. It demonstrates binding affinities with multiple subunits of the GABA-A receptor, showing strong affinity particularly for the alpha-1-beta-3-gamma-2 subunits (Ki = 57.0 nM) and moderate affinities for other subunits such as alpha-3-beta-3-gamma-2 (Ki = 1161.0 nM) and alpha-5-beta-3-gamma-2 (Ki = 561.0 nM). It binds to various GABA-A receptor subtypes with Ki values ranging from 57.0 nM to greater than 10000.0 nM, indicating selective bioactivity towards certain subtypes. Additionally, CL 218872 exhibits anticonvulsant activity, demonstrated by its efficacy in preventing convulsions in mice, and shows anxiolytic properties by protecting against pentylenetetrazole-induced convulsions.
Moreover, CL 218872 shows binding affinity for the benzodiazepine receptor (Ki = 198.0 nM) and relative binding to the central benzodiazepine receptor with a GABA ratio of 1.2 in the presence and absence of 10e-4 M GABA. This suggests potential modulation of GABAergic neurotransmission through interaction with benzodiazepine sites.
In addition to its neurological activities, CL 218872 has shown inhibitory effects on various targets, including enzymes like Cytochrome P450 3A4, ALDH1A1, and HPGD, and it exhibits antiviral activity against SARS-CoV-2, providing broad pharmacological potential. It inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells and demonstrates modest inhibition of SARS-CoV-2 3CL-Pro protease.
Overall, CL 218872 is a potent GABA-A receptor modulator with anticonvulsant and anxiolytic properties, alongside exhibiting significant enzymatic and antiviral bioactivities..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo. |
| Molecular Weight | 278.23 |
| Formula | C13H9F3N4 |
| Cas No. | 66548-69-4 |
| Smiles | CC=1N2C(C=CC(=N2)C3=CC(C(F)(F)F)=CC=C3)=NN1 |
| Relative Density. | 1.43g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 13.9 mg/mL (49.96 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy CL 218872 | purchase CL 218872 | CL 218872 cost | order CL 218872 | CL 218872 chemical structure | CL 218872 formula | CL 218872 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.