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SIRP gamma Protein, Human, Recombinant (His)

Catalog No. TMPY-01853
Synonyms: bA77C3.1, signal-regulatory protein gamma, SIRP γ/SIRPG, signal-regulatory protein γ, SIRPγ, SIRPB2, CD172g, SIRPgamma, SIRP-B2

SIRP gamma Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.5 kDa and the accession number is Q9P1W8-1.

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SIRP gamma Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
100 μg In stock $ 249.00
200 μg 5 days $ 442.00
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Biological Description
Technical Params
Product Properties
References and Literature
Biological Information Measured by its binding ability in a functional ELISA. Immobilized human SIRPG-His at 10 μg/ml (100 μl/well) can bind human CD47-Fc , The EC50 of human CD47-Fc is 0.58-1.34 μg/ml.

Description SIRP gamma Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.5 kDa and the accession number is Q9P1W8-1.
Species Human
Expression System HEK293 Cells
Tag C-His
Accession Number Q9P1W8-1
Synonyms bA77C3.1, signal-regulatory protein gamma, SIRP γ/SIRPG, signal-regulatory protein γ, SIRPγ, SIRPB2, CD172g, SIRPgamma, SIRP-B2
Construction The Human SIRPG (NP_061026.2) extracellular domain (Met1-Ser364) was expressed with a polyhistidine tag at the C-terminus.
Protein Purity ≥ 96 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.

Molecular Weight 38.5 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background Signal-regulatory protein gamma (SIRPG/SIRP gamma) also known as CD172 antigen-like family member B, CD172g, and CD172g antigen, is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. SIRPG/SIRP gamma/CD172g is a probable immunoglobulin-like cell surface receptor. On binding with CD47, SIRPG can mediate cell-cell adhesion. SIRPG/SIRP gamma is engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. SIRPG/SIRP gamma/CD172g is detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. This cytokine is mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, SIRPG is primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.

References and Literature

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Keywords

SIRP gamma Protein, Human, Recombinant (His) bA77C3.1 signal-regulatory protein gamma SIRPB-2 SIRP γ/SIRPG signal-regulatory protein γ SIRPγ SIRPB 2 SIRPB2 CD172g SIRPgamma SIRP-B2 recombinant recombinant-proteins proteins protein

 

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