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DCXR Protein, Human, Recombinant (His)

Catalog No. TMPY-03460
Synonyms: XR, P34H, HCR2, HCRII, PNTSU, SDR20C1, DCR, dicarbonyl/L-xylulose reductase, KIDCR

DCXR, also known as HCR2, belongs to the short-chain dehydrogenases/reductases (SDR) family. It is highly expressed in kidney, liver and epididymis. In the epididymis, DCXR is mainly expressed in the proximal and distal sections of the corpus region. HCR2 is weakly or not expressed in brain, lung, heart, spleen and testis. DCXR catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. DCXR participates in the uronate cycle of glucose metabolism. It may play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.

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DCXR Protein, Human, Recombinant (His)
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100 μg 5 days $ 600.00
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Biological Description
Technical Params
Product Properties
References and Literature
Description DCXR, also known as HCR2, belongs to the short-chain dehydrogenases/reductases (SDR) family. It is highly expressed in kidney, liver and epididymis. In the epididymis, DCXR is mainly expressed in the proximal and distal sections of the corpus region. HCR2 is weakly or not expressed in brain, lung, heart, spleen and testis. DCXR catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. DCXR participates in the uronate cycle of glucose metabolism. It may play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
Species Human
Expression System E. coli
Tag His
Accession Number Q7Z4W1
Synonyms XR, P34H, HCR2, HCRII, PNTSU, SDR20C1, DCR, dicarbonyl/L-xylulose reductase, KIDCR
Construction A DNA sequence encoding the mature form of human DCXR (Q7Z4W1) (Met1-Cys244) was expressed with a polyhistidine tag at the N-terminus.
Protein Purity > 95 % as determined by SDS-PAGE
Molecular Weight Approxiamtely 27.8 kDa
Endotoxin Please contact us for more information.
Formulation Supplied as sterile PBS, 20% Glycerol, pH 7.4. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping

Solution. It is shipped out with blue ice.

Research Background DCXR, also known as HCR2, belongs to the short-chain dehydrogenases/reductases (SDR) family. It is highly expressed in kidney, liver and epididymis. In the epididymis, DCXR is mainly expressed in the proximal and distal sections of the corpus region. HCR2 is weakly or not expressed in brain, lung, heart, spleen and testis. DCXR catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. DCXR participates in the uronate cycle of glucose metabolism. It may play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.

References and Literature

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Keywords

DCXR Protein, Human, Recombinant (His) XR P34H HCR2 HCR 2 HCR-2 HCRII PNTSU SDR20C1 DCR dicarbonyl/L-xylulose reductase KIDCR recombinant recombinant-proteins proteins protein

 

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