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9-ING-41

Name: 9-ING-41
Brand: TargetMol
SKU: T14066
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T14066 Copy Product Info

Purity: 99.32%

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9-ING-41 is a glycogen synthase kinase-3 inhibitor.

9-ING-41

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Catalog No. T14066

9-ING-41 is a glycogen synthase kinase-3 inhibitor.

Cas No. 1034895-42-5

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Pack Size	Price	USA Stock	Global Stock
1 mg	$45	In Stock	In Stock
2 mg	$64	In Stock	In Stock
5 mg	$101	In Stock	In Stock
10 mg	$166	In Stock	In Stock
25 mg	$343	In Stock	In Stock
50 mg	$497	In Stock	In Stock
100 mg	$742	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$118	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.32%

Appearance:Solid

Color:Red

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	9-ING-41 is a glycogen synthase kinase-3 inhibitor.
Targets&IC50	GSK-3β:0.71 μM (IC50)
In vitro	9-ING-41 (2, 4 μM; 48 hours) decreases neuroblastoma cell viability induces apoptosis[2]. 9-ING-41 (1, 2 μM; 24 hours) is a potent cell cycle-blocking agent for lymphoma cells[2]. 9-ING-41 (0.1-1 μM) inhibits GSK-3 leading to a decreased expression of the NF-κB target XIAP and significant apoptosis in neuroblastoma cells as shown by PARP cleavage, an apoptosis marker[1]. 9-ING-41 (0.5, 1.0, 1.5, 2.0 μM) inhibits the proliferation rate of all TCL and MCL lines with concentrations as low as 1.0 mM[2].
In vivo	In a mouse model of MCL, 9-ING-41 (40 mg/kg/every other day; for 17 days) has single-agent antitumor activity [2].

Chemical Properties

Molecular Weight	404.35
Formula	C₂₂H₁₃FN₂O₅
Cas No.	1034895-42-5
Smiles	Cn1cc(C2=C(C(=O)NC2=O)c2coc3ccc(F)cc23)c2cc3OCOc3cc12
Relative Density.	1.63 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (309.14 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4731 mL	12.3655 mL	24.7310 mL	123.6552 mL
5 mM	0.4946 mL	2.4731 mL	4.9462 mL	24.7310 mL
10 mM	0.2473 mL	1.2366 mL	2.4731 mL	12.3655 mL
20 mM	0.1237 mL	0.6183 mL	1.2366 mL	6.1828 mL
50 mM	0.0495 mL	0.2473 mL	0.4946 mL	2.4731 mL
100 mM	0.0247 mL	0.1237 mL	0.2473 mL	1.2366 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc