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Marstacimab
🥰Excellent
Catalog No. T81854Cas No. 1985638-39-8
Alias PF-6741086, PF6741086, PF-06741086, PF06741086
Marstacimab (PF-06741086) is a neutralizing antibody that binds to and inhibits inhibitors of the human tissue factor pathway. Marstacimab is an anti-tissue factor pathway inhibitor used in the study of hemophilia.
Marstacimab
Marstacimab
🥰Excellent
Catalog No. T81854Alias PF-6741086, PF6741086, PF-06741086, PF06741086Cas No. 1985638-39-8
Marstacimab (PF-06741086) is a neutralizing antibody that binds to and inhibits inhibitors of the human tissue factor pathway. Marstacimab is an anti-tissue factor pathway inhibitor used in the study of hemophilia.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $263 | In Stock | In Stock | |
| 5 mg | $723 | In Stock | In Stock | |
| 10 mg | $986 | - | In Stock | |
| 25 mg | $1,490 | - | In Stock | |
| 50 mg | $1,970 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.3% (SDS-PAGE); 99% (SEC-HPLC)
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Product Introduction
Bioactivity
Chemical Properties
| Description | Marstacimab (PF-06741086) is a neutralizing antibody that binds to and inhibits inhibitors of the human tissue factor pathway. Marstacimab is an anti-tissue factor pathway inhibitor used in the study of hemophilia. |
| In vitro | Marstacimab was able to reduce corn trypsin (CT) levels in whole blood samples from hemophiliacs at concentrations of 20, 50 and 100 nmol/L. [1] In an in vitro assay, Marstacimab (16 μg/mL) not only shortened the clotting lag time and increased thrombin generation in human non-hemophilic platelet depleted plasma samples, but also increased peak thrombin in hemophilia A and hemophilia B plasma samples. [2] |
| In vivo | In a mouse model of acute hemorrhage, Marstacimab administered intravenously at a dose of 0.5 mg/kg had no hemodynamic effects. [2] |
| Synonyms | PF-6741086, PF6741086, PF-06741086, PF06741086 |
| Cas No. | 1985638-39-8 |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: buy Marstacimab | purchase Marstacimab | Marstacimab cost | order Marstacimab | Marstacimab in vivo | Marstacimab in vitro
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