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C3a Receptor Agonist
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Catalog No. T38287Cas No. 944997-60-8
Alias Complement 3a Receptor Agonist, C3a receptor agonist 1
C3a Receptor Agonist (C3a receptor agonist 1) binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR prevents neutrophils from being mobilized in a model of intestinal ischemia-reperfusion injury. C3aRs are expressed on neural progenitor cells and immature neurons in adult mice. C3a stimulates differentiation of neural progenitor cells in vitro.
C3a Receptor Agonist
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Purity: 99.76%
Catalog No. T38287Alias Complement 3a Receptor Agonist, C3a receptor agonist 1Cas No. 944997-60-8
C3a Receptor Agonist (C3a receptor agonist 1) binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR prevents neutrophils from being mobilized in a model of intestinal ischemia-reperfusion injury. C3aRs are expressed on neural progenitor cells and immature neurons in adult mice. C3a stimulates differentiation of neural progenitor cells in vitro.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $89 | In Stock | In Stock | |
| 5 mg | $318 | In Stock | In Stock | |
| 10 mg | $538 | In Stock | In Stock | |
| 25 mg | $868 | In Stock | In Stock | |
| 50 mg | $1,170 | In Stock | In Stock | |
| 100 mg | $1,580 | - | In Stock | |
| 500 mg | $3,170 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.76%
Appearance:Solid
Color:White
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Product Introduction
C3a Receptor Agonist AI Summary
C3a Receptor Agonist exhibits bioactivities including C3a receptor agonist activity with an EC50 value of 1995.26 nM and the ability to displace [125I]C3a from the human C3a receptor with an IC50 of 794.33 nM. It shows moderate permeability across Caco-2 cells, with a permeability value of 12.0 x 10^-6 cm/s. In terms of metabolism and excretion, the compound has a clearance of 500.0 μL/min in rat microsomes and 33.0 μL/min in rat hepatocytes. It has an elimination half-life of 0.2 hours in rats at a dose of 1 mg/kg (both intravenous and oral) and demonstrates 5.0% oral bioavailability at the same dose..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | C3a Receptor Agonist (C3a receptor agonist 1) binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR prevents neutrophils from being mobilized in a model of intestinal ischemia-reperfusion injury. C3aRs are expressed on neural progenitor cells and immature neurons in adult mice. C3a stimulates differentiation of neural progenitor cells in vitro. |
| Synonyms | Complement 3a Receptor Agonist, C3a receptor agonist 1 |
| Molecular Weight | 433.59 |
| Formula | C27H35N3O2 |
| Cas No. | 944997-60-8 |
| Smiles | O=C(CCc1cccnc1)N1CCC(CC1)NC(=O)C(C1CCCCC1)c1ccccc1 |
| Relative Density. | 1.15 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMF: 30 mg/mL (69.19 mM), Sonication is recommended. DMSO: 40 mg/mL (92.25 mM), Sonication is recommended. Ethanol: 30 mg/mL (69.19 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMF/Ethanol/DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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