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Anti-CD98 Antibody (7T288)
😃Good
Catalog No. TMAY-02280
Alias solute carrier family 3 (amino acid transporter heavy chain), member 2, NACAE, MDU1, CD98HC, CD98, 4T2HC, 4F2HC, 4F2
Anti-CD98 Antibody (7T288) is a Rabbit antibody targeting CD98. Anti-CD98 Antibody (7T288) can be used in ELISA.
Anti-CD98 Antibody (7T288)
Anti-CD98 Antibody (7T288)
😃Good
Catalog No. TMAY-02280Alias solute carrier family 3 (amino acid transporter heavy chain), member 2, NACAE, MDU1, CD98HC, CD98, 4T2HC, 4F2HC, 4F2
Anti-CD98 Antibody (7T288) is a Rabbit antibody targeting CD98. Anti-CD98 Antibody (7T288) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Chemical Properties
| Description | Anti-CD98 Antibody (7T288) is a Rabbit antibody targeting CD98. Anti-CD98 Antibody (7T288) can be used in ELISA. |
| Alias | solute carrier family 3 (amino acid transporter heavy chain), member 2, NACAE, MDU1, CD98HC, CD98, 4T2HC, 4F2HC, 4F2 |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 7T288 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human CD98 / SLC3A2 (rh CD98 / SLC3A2; TMPY-01938; P08195-1; Arg206-Ala630). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | 4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein that belongs to the SLC3A transporter family. SLC3A2 / MDU1 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta is significantly stronger at full-term than at the mid-trimester stage. SLC3A2 / MDU1 is expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. It is expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. SLC3A2 / MDU1 is also expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco2-BBE. SLC3A2 / MDU1 is required for the function of light chain amino-acid transporters. It is involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. SLC3A2 / MDU1 is involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7, SLC3A2 / MDU1 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. SLC3A2 / MDU1 plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. It is required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, SLC3A2 / MDU1 is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human CD98 / SLC3A2 Protein (TMPY-01938) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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