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Tilfrinib

Name: Tilfrinib
Brand: TargetMol
SKU: T17098
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T17098Cas No. 1600515-49-8

Tilfrinib is an effective and selective inhibitor of breast tumor kinase(Brk, IC50 = 3.15 nM) which displays anti-proliferative and anti-tumor activities.

Tilfrinib

🥰Excellent

Purity: 99.54%

Catalog No. T17098Cas No. 1600515-49-8

Tilfrinib is an effective and selective inhibitor of breast tumor kinase(Brk, IC50 = 3.15 nM) which displays anti-proliferative and anti-tumor activities.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	In Stock	In Stock
2 mg	$54	In Stock	In Stock
5 mg	$89	In Stock	In Stock
10 mg	$139	In Stock	In Stock
25 mg	$269	In Stock	In Stock
50 mg	$488	In Stock	In Stock
100 mg	$716	In Stock	In Stock
500 mg	$1,480	-	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.54%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Tilfrinib is an effective and selective inhibitor of breast tumor kinase(Brk, IC50 = 3.15 nM) which displays anti-proliferative and anti-tumor activities.
Targets&IC50	Brk:3.15 nM
In vitro	Tilfrinib is against MCF7, HS-578/T, and BT-549 cells with GI50 values of 0.99, 1.02 and 1.58 µM[2].

Chemical Properties

Molecular Weight	275.3
Formula	C₁₇H₁₃N₃O
Cas No.	1600515-49-8
Smiles	Oc1cccc(Nc2ccnc3[nH]c4ccccc4c23)c1
Relative Density.	1.421 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 112.5 mg/mL (408.65 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (14.53 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6324 mL	18.1620 mL	36.3240 mL	181.6201 mL
5 mM	0.7265 mL	3.6324 mL	7.2648 mL	36.3240 mL
10 mM	0.3632 mL	1.8162 mL	3.6324 mL	18.1620 mL
20 mM	0.1816 mL	0.9081 mL	1.8162 mL	9.0810 mL
50 mM	0.0726 mL	0.3632 mL	0.7265 mL	3.6324 mL
100 mM	0.0363 mL	0.1816 mL	0.3632 mL	1.8162 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc