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Lqvtdsglyrcviyhpp TFA

Name: Lqvtdsglyrcviyhpp TFA
Brand: TargetMol
SKU: T78026
Price: 60 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78026

LQVTDSGLYRCVIYHPP (LP17) TFA is a TREM-1 (triggering receptor expressed on myeloid cells) inhibitory peptide that significantly reduces ischemic infarction and neuronal damage, with the ability to penetrate the brain to inhibit TREM-1 [1].

Lqvtdsglyrcviyhpp TFA

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Purity: 95%

Catalog No. T78026

Pack Size	Price	Availability
1 mg	$60	In Stock
5 mg	$147	In Stock
10 mg	$216	In Stock

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Purity:95%

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Product Introduction

Bioactivity

Description	LQVTDSGLYRCVIYHPP (LP17) TFA is a TREM-1 (triggering receptor expressed on myeloid cells) inhibitory peptide that significantly reduces ischemic infarction and neuronal damage, with the ability to penetrate the brain to inhibit TREM-1 [1].
In vitro	METHODS: LQVTDSGLYRCVIYHPP (LP17) TFA (1 or 10 μM) was used in microglia to investigate the function of TREM-1 in the microglial OGD model by real-time quantitative PCR. RESULTS: LQVTDSGLYRCVIYHPP (LP17) TFA significantly reduced the mRNA levels of proinflammatory cytokines (NLRP3, IL-1β, IL-18, IL-6, CD16, CD32, and iNOS) and chemokines (MCP-1, CXCL-1, and CXCL-2); microglia incubated with LQVTDSGLYRCVIYHPP (LP17) maximally preserved neuronal viability. [1]
In vivo	METHODS: LQVTDSGLYRCVIYHPP (LP17) TFA (1 mg/kg, intranasal) was used to confirm the biological function of TREM-1 in ischemic stroke. RESULTS: LQVTDSGLYRCVIYHPP (LP17) TFA induced a significant decrease in TUNEL-positive cells and FJC-positive neurons. [1]

Chemical Properties

Molecular Weight	2075.27
Formula	C₉₁H₁₃₈F₃N₂₃O₂₇S
Smiles	[H]N[C@H](C(N[C@H](C(N[C@H](C(N[C@]([H])(C(N[C@@H](CC(O)=O)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@H](C(N[C@@H](CS)C(N[C@H](C(N[C@]([H])(C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC3=CN=CN3)C(N4CCC[C@H]4C(N5CCC[C@H]5C(O)=O)=O)=O)=O)=O)[C@@H](C)CC)=O)C(C)C)=O)=O)CCCNC(N)=N)=O)=O)CC(C)C)=O)=O)CO)=O)=O)[C@H](O)C)=O)C(C)C)=O)CCC(N)=O)=O)CC(C)C.OC(C(F)(F)F)=O
Sequence	H-Leu-Gln-Val-Thr-Asp-Ser-Gly-Leu-Tyr-Arg-Cys-Val-Ile-Tyr-His-Pro-Pro-OH
Sequence Short	LQVTDSGLYRCVIYHPP

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble)

DMSO: 80 mg/mL (38.55 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (1.59 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.4819 mL	2.4093 mL	4.8187 mL	24.0933 mL
5 mM	0.0964 mL	0.4819 mL	0.9637 mL	4.8187 mL
10 mM	0.0482 mL	0.2409 mL	0.4819 mL	2.4093 mL
20 mM	0.0241 mL	0.1205 mL	0.2409 mL	1.2047 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc