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ATP-γ-S tetrasodium

Name: ATP-γ-S tetrasodium
Brand: TargetMol
SKU: T83827
Rating: 4.5 (1 reviews)

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Catalog No. T83827Cas No. 88453-52-5

Alias ATPγS tetrasodium, Adenosine-5'-O-(3-thiotriphosphate) tetrasodium, Adenosine 5'-(γ-thio)-triphosphate tetrasodium

ATP-γ-S tetrasodium (Adenosine-5'-O-(3-thiotriphosphate) tetrasodium) is a purinergic P2Y11 receptor agonist and ATP analog that induces inositol phosphate accumulation, induces insulin secretion from MIN6 pancreatic islet β-cells, and induces an increase in intracellular calcium concentration. ATP-γ-S tetrasodium inhibits the induction of the Junin virus. Junin virus-induced increase in the level of mRNA encoding bone morphogenetic protein 6 (BMP6) reduces particle-forming units (PFUs) in Junin virus-infected primary rat osteoblasts.

ATP-γ-S tetrasodium

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Catalog No. T83827Alias ATPγS tetrasodium, Adenosine-5'-O-(3-thiotriphosphate) tetrasodium, Adenosine 5'-(γ-thio)-triphosphate tetrasodiumCas No. 88453-52-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2600 μg	$398	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Liquid

Color:Transparent

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Product Introduction

Bioactivity

Description	ATP-γ-S tetrasodium (Adenosine-5'-O-(3-thiotriphosphate) tetrasodium) is a purinergic P2Y11 receptor agonist and ATP analog that induces inositol phosphate accumulation, induces insulin secretion from MIN6 pancreatic islet β-cells, and induces an increase in intracellular calcium concentration. ATP-γ-S tetrasodium inhibits the induction of the Junin virus. Junin virus-induced increase in the level of mRNA encoding bone morphogenetic protein 6 (BMP6) reduces particle-forming units (PFUs) in Junin virus-infected primary rat osteoblasts.
In vitro	ATP-γ-S tetrasodium enhances spinach Rubisco activase activity by enhancing autofluorescence and inducing aggregation. [1] ATP-γ-S tetrasodium (final blood concentration 50-100 μM) attenuated the inflammatory response as evidenced by a 48% reduction in cell accumulation and a 57% reduction in protein content in bronchoalveolar lavage fluid, as well as a reduction in neutrophil infiltration and a decrease in the number of neutrophils. exudation of Evans blue albumin dye in lung tissue. [3]
In vivo	50 μM ATP-γ-S tetrasodium, i.v., protected lung parenchymal structures. [3] In LPS-treated mice, ATP-γ-S tetrasodium showed a dose-dependent effect on EBA exudation. [3]
Synonyms	ATPγS tetrasodium, Adenosine-5'-O-(3-thiotriphosphate) tetrasodium, Adenosine 5'-(γ-thio)-triphosphate tetrasodium

Chemical Properties

Molecular Weight	611.17
Formula	C₁₀H₁₂N₅Na₄O₁₂P₃S
Cas No.	88453-52-5
Smiles	O[C@H]1[C@@H](O[C@@H]([C@H]1O)COP(OP(OP([O-])([S-])=O)([O-])=O)([O-])=O)N2C3=NC=NC(N)=C3N=C2.[Na+].[Na+].[Na+].[Na+]

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 5 mg/mL (8.18 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.6362 mL	8.1810 mL	16.3621 mL	81.8103 mL
5 mM	0.3272 mL	1.6362 mL	3.2724 mL	16.3621 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc