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Anti-NGAL/Lipocalin-2 Polyclonal Antibody is a Rabbit antibody targeting NGAL/Lipocalin-2. Anti-NGAL/Lipocalin-2 Polyclonal Antibody can be used in ELISA,IF,IHC-Fr,IHC-P.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $220 | 7-10 days | |
100 μL | $373 | 7-10 days | |
200 μL | $528 | 7-10 days |
Description | Anti-NGAL/Lipocalin-2 Polyclonal Antibody is a Rabbit antibody targeting NGAL/Lipocalin-2. Anti-NGAL/Lipocalin-2 Polyclonal Antibody can be used in ELISA,IF,IHC-Fr,IHC-P. |
Synonyms | Siderocalin LCN2, p25, Oncogene 24p3, NGAL, MSFI, Lipocalin-2 |
Ig Type | IgG |
Reactivity | Human |
Verified Activity | Tissue/cell: human colon carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer (0.01M, pH6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37°C for 20 min; Incubation: Anti-NGAL Polyclonal Antibody, Unconjugated (TMAB-01234) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody and DAb staining. |
Application | |
Recommended Dose | IHC-P: 1:400-800; IHC-Fr: 1:400-800; IF: 1:100-500; ELISA: 1:5000-10000 |
Antibody Type | Polyclonal |
Host Species | Rabbit |
Subcellular Localization | Secreted. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized. |
Tissue Specificity | Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or pe |
Construction | Polyclonal Antibody |
Purification | Protein A purified |
Appearance | Liquid |
Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Concentration | 1 mg/mL |
Research Background | Lipocalin 2 is a member of the lipocalin family which encompass more than 25 members (including proteins like retinol binding protein, a1 microglobulin, b lactoglobulin, apolipoprotein D and odorant binding protein). The members of the lipocalin family are characterized by their ability to bind small lipophilic substances in their hydrophobic core, and thereby serve as transporters of substances. |
Immunogen | KLH conjugated synthetic peptide: human Lipocalin 2 |
Antigen Species | Human |
Gene Name | LCN2 |
Gene ID | |
Protein Name | Neutrophil gelatinase-associated lipocalin |
Uniprot ID | |
Biology Area | Tumor biomarkers,Binding proteins,Non-CD,Fatty acids,Fatty acid oxidation,Cancer,Lipid metabolism |
Function | Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. |
Molecular Weight | Theoretical: 20 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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