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Anti-NGAL/Lipocalin-2 Polyclonal Antibody

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Catalog No. TMAB-01234
Alias Siderocalin LCN2, p25, Oncogene 24p3, NGAL, MSFI, Lipocalin-2

Anti-NGAL/Lipocalin-2 Polyclonal Antibody is a Rabbit antibody targeting NGAL/Lipocalin-2. Anti-NGAL/Lipocalin-2 Polyclonal Antibody can be used in ELISA,IF,IHC-Fr,IHC-P.

Anti-NGAL/Lipocalin-2 Polyclonal Antibody

Anti-NGAL/Lipocalin-2 Polyclonal Antibody

😃Good
Catalog No. TMAB-01234Alias Siderocalin LCN2, p25, Oncogene 24p3, NGAL, MSFI, Lipocalin-2
Anti-NGAL/Lipocalin-2 Polyclonal Antibody is a Rabbit antibody targeting NGAL/Lipocalin-2. Anti-NGAL/Lipocalin-2 Polyclonal Antibody can be used in ELISA,IF,IHC-Fr,IHC-P.
Pack SizePriceAvailabilityQuantity
50 μL$2207-10 days
100 μL$3737-10 days
200 μL$5287-10 days
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Product Introduction

Bioactivity
Description
Anti-NGAL/Lipocalin-2 Polyclonal Antibody is a Rabbit antibody targeting NGAL/Lipocalin-2. Anti-NGAL/Lipocalin-2 Polyclonal Antibody can be used in ELISA,IF,IHC-Fr,IHC-P.
SynonymsSiderocalin LCN2, p25, Oncogene 24p3, NGAL, MSFI, Lipocalin-2
Ig Type
IgG
Reactivity
Human
Verified Activity
Tissue/cell: human colon carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer (0.01M, pH6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37°C for 20 min;
Incubation: Anti-NGAL Polyclonal Antibody, Unconjugated (TMAB-01234) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody and DAb staining.
Application
Recommended Dose
IHC-P: 1:400-800; IHC-Fr: 1:400-800; IF: 1:100-500; ELISA: 1:5000-10000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationSecreted. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized.
Tissue SpecificityExpressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or pe
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1 mg/mL
Research BackgroundLipocalin 2 is a member of the lipocalin family which encompass more than 25 members (including proteins like retinol binding protein, a1 microglobulin, b lactoglobulin, apolipoprotein D and odorant binding protein). The members of the lipocalin family are characterized by their ability to bind small lipophilic substances in their hydrophobic core, and thereby serve as transporters of substances.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human Lipocalin 2
Antigen Species
Human
Gene Name
LCN2
Gene ID
Protein Name
Neutrophil gelatinase-associated lipocalin
Uniprot ID
Biology Area
Tumor biomarkers,Binding proteins,Non-CD,Fatty acids,Fatty acid oxidation,Cancer,Lipid metabolism
Function
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
Chemical Properties
Molecular WeightTheoretical: 20 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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