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Resolvin E1

Name: Resolvin E1
Brand: TargetMol
SKU: T16733
Rating: 4.5 (1 reviews)

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Catalog No. T16733Cas No. 552830-51-0

Alias Nocertone, L-6257, L6257

Resolvin E1 (RvE1) is an endogenous lipid mediator derived from the omega-3 fatty acid eicosapentaenoic acid (EPA). It exhibits anti-inflammatory properties, activates inflammation resolution, and promotes phagocytic clearance. It prevents 2,4,6-trinitrobenzenesulfonic acid-induced colitis and improves erythrocytosis and severe aplastic anaemia (SAA).

Resolvin E1

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Catalog No. T16733Alias Nocertone, L-6257, L6257Cas No. 552830-51-0

Pack Size	Price	USA Warehouse	Global Warehouse
10 μg	$429	35 days	35 days
25 μg	$990	35 days	35 days
50 μg	$1,850	35 days	35 days
100 μg	$3,260	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solution

Color:Transparent

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Product Introduction

Bioactivity

Description	Resolvin E1 (RvE1) is an endogenous lipid mediator derived from the omega-3 fatty acid eicosapentaenoic acid (EPA). It exhibits anti-inflammatory properties, activates inflammation resolution, and promotes phagocytic clearance. It prevents 2,4,6-trinitrobenzenesulfonic acid-induced colitis and improves erythrocytosis and severe aplastic anaemia (SAA).
In vitro	Resolvin E1 specifically interacts with the LTB4 receptor BLT1 on neutrophils and ChemR23 on monocytes to regulate leukocytes during inflammation. Resolvin E1 also stimulates the uptake and clearance of local cytokine. Resolvin E1 (0.1-100 nM) gives concentration-dependent inhibition of TNF-α–induced NF-κB activation (EC50: ～1.0 nM in ChemR23-transfected cells). Resolvin E1 (100 nM) enhances phosphorylation of ERK mitogen-activated protein (MAP) kinase both in peripheral blood monocytes and HEK-ChemR23 cells [2][3].
In vivo	Resolvin E1 (1.0 μg per mouse; 50 μg/kg; i.p.; on days -8, -1, and 0) protects mice from TNBS colitis[1].
Synonyms	Nocertone, L-6257, L6257

Chemical Properties

Molecular Weight	350.45
Formula	C₂₀H₃₀O₅
Cas No.	552830-51-0
Smiles	C([C@@H](/C=C\C=C\C=C\[C@@H](C/C=C\C=C\[C@@H](CC)O)O)O)CCC(O)=O
Relative Density.	1.112 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 40 mg/mL (114.14 mM), Sonication and heating are recommended.

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.8535 mL	14.2674 mL	28.5347 mL	142.6737 mL
5 mM	0.5707 mL	2.8535 mL	5.7069 mL	28.5347 mL
10 mM	0.2853 mL	1.4267 mL	2.8535 mL	14.2674 mL
20 mM	0.1427 mL	0.7134 mL	1.4267 mL	7.1337 mL
50 mM	0.0571 mL	0.2853 mL	0.5707 mL	2.8535 mL
100 mM	0.0285 mL	0.1427 mL	0.2853 mL	1.4267 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc