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Semorinemab
😃Good
Catalog No. T76886Cas No. 2159141-27-0
Alias RO-7105705, RO7105705, RG6100, RG 6100, MTAU-9937A, MTAU9937A
Semorinemab (RG6100) is a humanised monoclonal antibody targeting the N-terminal domain of tau protein with a Kd of 3.8 nM, suitable for Alzheimer's disease research. It binds all six human tau isoforms and reduces tau accumulation.
Semorinemab
Semorinemab
😃Good
Purity: 95%
Catalog No. T76886Alias RO-7105705, RO7105705, RG6100, RG 6100, MTAU-9937A, MTAU9937ACas No. 2159141-27-0
Semorinemab (RG6100) is a humanised monoclonal antibody targeting the N-terminal domain of tau protein with a Kd of 3.8 nM, suitable for Alzheimer's disease research. It binds all six human tau isoforms and reduces tau accumulation.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $247 | - | In Stock | |
| 5 mg | $645 | - | In Stock | |
| 10 mg | $987 | - | In Stock | |
| 25 mg | $1,460 | - | In Stock | |
| 50 mg | $1,970 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:96.7% (SDS-PAGE); 97.2% (SEC-HPLC)
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| Description | Semorinemab (RG6100) is a humanised monoclonal antibody targeting the N-terminal domain of tau protein with a Kd of 3.8 nM, suitable for Alzheimer's disease research. It binds all six human tau isoforms and reduces tau accumulation. |
| In vitro | The binding dissociation constants (Kd) of Semorinemab with Homo sapiens-derived Tau protein and recombinant cynomolgus monkey Tau protein (Bletilla striata) were 3.8 nM and 11.2 nM, respectively [1]. Semorinemab effectively inhibits neuronal uptake of Tau oligomers [1]. |
| In vivo | In the Tau pathology transgenic (Tg) mouse model, Semorinemab (3, 10, and 30 mg/kg; intraperitoneal injection, once weekly for 13 weeks) effectively reduced Tau protein accumulation. |
| Synonyms | RO-7105705, RO7105705, RG6100, RG 6100, MTAU-9937A, MTAU9937A |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | Tau |
| Molecular Weight | 145.24 kDa |
| Cas No. | 2159141-27-0 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG4 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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