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CDK12-IN-7 (Compound 2), a dual inhibitor of CDK12 and CDK2, exhibits IC 50 values of 42 nM and 196 nM, respectively. This compound demonstrates anti-cell proliferation properties, making it applicable in cancer research.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,820 | 10-14 weeks | 10-14 weeks | |
| 50 mg | $2,380 | 10-14 weeks | 10-14 weeks | |
| 100 mg | $3,100 | 10-14 weeks | 10-14 weeks |
| Description | CDK12-IN-7 (Compound 2), a dual inhibitor of CDK12 and CDK2, exhibits IC 50 values of 42 nM and 196 nM, respectively. This compound demonstrates anti-cell proliferation properties, making it applicable in cancer research. |
| Targets&IC50 | CDK2:196 nM, CDK12:42 nM |
| In vitro | CDK12-IN-7 inhibits the proliferation of A2780 cells, with an IC50 value of 429 nM [1]. |
| Molecular Weight | 663.65 |
| Formula | C32H32F3N9O4 |
| Cas No. | 3033863-94-1 |
| Smiles | CN1C=2N(C=3C(N2)=NC(N(C(NCC4=CC=CC=C4)=O)[C@@H]5CC[C@@H](NC=6N=C(OC7COC7)C(C(F)(F)F)=CN6)CC5)=CC3)C=CC1=O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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