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SR-3306

Name: SR-3306
Brand: TargetMol
SKU: T16927
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16927Cas No. 1128096-91-2

SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM, respectively, and reduces food intake and body weight.

SR-3306

🥰Excellent

Purity: 99.71%

Catalog No. T16927Cas No. 1128096-91-2

SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM, respectively, and reduces food intake and body weight.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$44	In Stock	In Stock
5 mg	$105	In Stock	In Stock
10 mg	$163	In Stock	In Stock
25 mg	$319	In Stock	In Stock
50 mg	$578	In Stock	In Stock
100 mg	$928	In Stock	In Stock
500 mg	$1,860	-	In Stock
1 mL x 10 mM (in DMSO)	$116	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.71%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM, respectively, and reduces food intake and body weight.
In vitro	METHODS: SR-3306 (0.001-100 μM) was used to treat cisplatin-resistant ovarian cancer cells to study its anticancer activity. RESULTS SR-3306 had inhibitory activity against cisplatin-resistant ovarian cancer cells, with an IC50 value of 0.05 μM. [4]
In vivo	METHODS: Dopaminergic neurons were labeled with antibodies against tyrosine hydroxylase (TH) in brain sections from rats treated with 6-OHDA. Rats received SR-3306 (2.5 mg/kg, 10 mg/kg, subcutaneously, for 14 days). The ability of SR-3306 to prevent nigrostriatal neuronal loss was examined in the 6-OHDA model. RESULTS 6-OHDA-lesioned rats treated with 2.5 mg/kg SR-3306 showed a slight increase in ipsilateral TH-positive neurons, and 10 mg/kg SR-3306 had a significant protective effect against 6-OHDA-induced neurodegeneration when the contralateral side was compared with the ipsilateral side. [1] METHODS: Wild-type lean mice were given SR3306 (30, 60 mg/kg, intraperitoneal injection) to study the effects of SR3306 on food intake and energy balance. RESULTS 30 mg/kg of SR3306 did not affect saccharin intake preference, while a dose of 60 mg/kg produced a strong avoidance response to saccharin. [2]

Chemical Properties

Molecular Weight	490.56
Formula	C₂₈H₂₆N₈O
Cas No.	1128096-91-2
Smiles	Cc1ccc(cn1)-c1ncn(n1)-c1ccc(Nc2nccc(n2)-c2cccc(c2)N2CCOCC2)cc1
Relative Density.	1.33 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (254.81 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0385 mL	10.1924 mL	20.3849 mL	101.9243 mL
5 mM	0.4077 mL	2.0385 mL	4.0770 mL	20.3849 mL
10 mM	0.2038 mL	1.0192 mL	2.0385 mL	10.1924 mL
20 mM	0.1019 mL	0.5096 mL	1.0192 mL	5.0962 mL
50 mM	0.0408 mL	0.2038 mL	0.4077 mL	2.0385 mL
100 mM	0.0204 mL	0.1019 mL	0.2038 mL	1.0192 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc