Protein-Tyrosine Phosphatase 1C (PTP1C) belongs to the protein-tyrosine phosphatase family.which is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1C is highly expressed in leukocyte cell type. It contains two SH2 domains and one tyrosine-protein phosphatase domain. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. In addition, PTP1C also modulates signaling by tyrosine phosphorylated cell surface receptors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 μg | 5 days | $ 184.00 | |
50 μg | 5 days | $ 545.00 | |
500 μg | 5 days | $ 1,900.00 | |
1 mg | 5 days | $ 2,730.00 |
Description | Protein-Tyrosine Phosphatase 1C (PTP1C) belongs to the protein-tyrosine phosphatase family.which is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1C is highly expressed in leukocyte cell type. It contains two SH2 domains and one tyrosine-protein phosphatase domain. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. In addition, PTP1C also modulates signaling by tyrosine phosphorylated cell surface receptors. |
Species | Human |
Expression System | E. coli |
Tag | C-6His |
Accession Number | P29350-3 |
Synonyms | HCP, Hematopoietic Cell Protein-Tyrosine Phosphatase, SH-PTP1, Protein-Tyrosine Phosphatase 1C, Protein-Tyrosine Phosphatase SHP-1, PTPN6, Tyrosine-Protein Phosphatase Non-Receptor Type 6, PTP-1C, PTP1C |
Amino Acid | Lys243-Ile541 |
Construction | Recombinant Human Protein-Tyrosine Phosphatase 1C is produced by our E.coli expression system and the target gene encoding Lys243-Ile541 is expressed with a 6His tag at the C-terminus. |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
Molecular Weight | 34 KDa, reducing conditions |
Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Supplied as a 0.2 μm filtered solution of 25mM Tris-HCl, 500mM NaCl, 2mM 2-Mercaptoethanol, 1mM EDTA, 1mM DTT, 20% Glycerol, pH7.5. |
Stability & Storage |
Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
Shipping |
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
Research Background | Protein-Tyrosine Phosphatase 1C (PTP1C) belongs to the protein-tyrosine phosphatase family.which is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1C is highly expressed in leukocyte cell type. It contains two SH2 domains and one tyrosine-protein phosphatase domain. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. In addition, PTP1C also modulates signaling by tyrosine phosphorylated cell surface receptors. |
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PTP1C Protein, Human, Recombinant (His) HCP Hematopoietic Cell Protein-Tyrosine Phosphatase SH-PTP1 PTPN 6 PTPN-6 Protein-Tyrosine Phosphatase 1C Protein-Tyrosine Phosphatase SHP-1 PTPN6 Tyrosine-Protein Phosphatase Non-Receptor Type 6 PTP-1C PTP1C recombinant recombinant-proteins proteins protein