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Ivachtin

Name: Ivachtin
Brand: TargetMol
SKU: T11696
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11696Cas No. 745046-84-8

Alias Caspase-3 Inhibitor VII

Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining caspases.

Ivachtin

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Purity: 99.74%

Catalog No. T11696Alias Caspase-3 Inhibitor VIICas No. 745046-84-8

Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining caspases.

Pack Size	Price	Availability
1 mg	$98	In Stock
5 mg	$247	In Stock
10 mg	$396	In Stock

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Purity:99.74%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining caspases.
Targets&IC50	Caspase-3:23 nM
In vitro	Ivachtin has protective effect in a model of staurosporininduced apoptosis in human Jurkat T cells.
Synonyms	Caspase-3 Inhibitor VII

Chemical Properties

Molecular Weight	447.46
Formula	C₂₀H₂₁N₃O₇S
Cas No.	745046-84-8
Smiles	O=C1C=2C=3C(N=C(C)C2C(=O)N1CCOC(C)=O)=CC=C(S(=O)(=O)N4CCOCC4)C3
Relative Density.	1.459 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: slightly soluble

DMF: 2 mg/mL (4.47 mM), Sonication is recommended.

Solution Preparation Table

DMF

	1mg	5mg	10mg	50mg
1 mM	2.2348 mL	11.1742 mL	22.3484 mL	111.7418 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc