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Boc-Leu-Gly-Arg-AMC
🥰Excellent
Catalog No. TP2169Cas No. 65147-09-3
Boc-Leu-Gly-Arg-AMC is a specific fluorogenic substrate designed for the enzymatic detection and quantification of complement component C3/C5 convertases, coagulation factor Xa, and soybean trypsin-like enzyme activity. Boc-Leu-Gly-Arg-AMC is also susceptible to hydrolysis by macropain, a high molecular weight thiol proteinase isolated from human erythrocytes, making it a versatile tool for enzymatic assays.
Boc-Leu-Gly-Arg-AMC
🥰Excellent
Purity: 99.53%
Catalog No. TP2169Cas No. 65147-09-3
Boc-Leu-Gly-Arg-AMC is a specific fluorogenic substrate designed for the enzymatic detection and quantification of complement component C3/C5 convertases, coagulation factor Xa, and soybean trypsin-like enzyme activity. Boc-Leu-Gly-Arg-AMC is also susceptible to hydrolysis by macropain, a high molecular weight thiol proteinase isolated from human erythrocytes, making it a versatile tool for enzymatic assays.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $44 | In Stock | |
| 5 mg | $98 | In Stock | |
| 10 mg | $158 | In Stock | |
| 25 mg | $272 | In Stock | |
| 50 mg | $413 | In Stock | |
| 100 mg | $589 | In Stock | |
| 200 mg | $839 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $147 | In Stock |
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Purity:99.53%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Boc-Leu-Gly-Arg-AMC is a specific fluorogenic substrate designed for the enzymatic detection and quantification of complement component C3/C5 convertases, coagulation factor Xa, and soybean trypsin-like enzyme activity. Boc-Leu-Gly-Arg-AMC is also susceptible to hydrolysis by macropain, a high molecular weight thiol proteinase isolated from human erythrocytes, making it a versatile tool for enzymatic assays. |
| In vitro | To demonstrate the presence of proteolytic enzymes capable of producing sodifrin in the abdominal gland, polybutoxycarbo-nyl (Boc)-Leu-Gly-Arg-4-methylcoumaryl-7-amide (MCA) and Boc-Leu-Leu-Lys-MCA were used as synthetic substrates. Crude extracts of the abdominal gland hydrolyzed both substrates to release 7-amino-4-methylcoumarin, indicating the presence of enzymes in the gland that generate sodifrin from its precursor molecule. The activity of the extracts to cleave Boc-Leu-Gly-Arg-AMC was optimal at pH 9.0 and 45°C, while the activity to cleave Boc-Leu-Leu-Lys-MCA was optimal at pH 9.0 and 40°C. [1] |
| Molecular Weight | 601.69 |
| Formula | C29H43N7O7 |
| Cas No. | 65147-09-3 |
| Smiles | CC=1C=2C(=CC(NC([C@@H](NC(CNC([C@@H](NC(OC(C)(C)C)=O)CC(C)C)=O)=O)CCCNC(=N)N)=O)=CC2)OC(=O)C1 |
| Relative Density. | 1.31g/cm3 |
| Sequence | Boc-Leu-Gly-Arg-AMC |
| Sequence Short | Boc-LGR-AMC |
Storage & Solubility Information
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (132.96 mM), Sonication is recommended. H2O: < 0.1 mg/mL (insoluble), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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