AMIGO2 Protein, Human, Recombinant (His)

Name: AMIGO2 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-03387
Rating: 4.5 (1 reviews)

(Synonyms: DEGA, AMIGO-2, ALI1, adhesion molecule with Ig-like domain 2) Copy Product Info

Synonyms: DEGA, AMIGO-2, ALI1, adhesion molecule with Ig-like domain 2

Catalog No. TMPY-03387 Copy Product Info

AMIGO2 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q86SJ2.

Pack Size	Price	USA Stock	Global Stock
5 µg	$108	7-10 days	7-10 days
10 µg	$178	7-10 days	7-10 days
20 µg	$296	7-10 days	7-10 days
50 µg	$696	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it.
Description	AMIGO2 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q86SJ2.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q86SJ2
Construction	Val40-Thr398
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	DEGA, AMIGO-2, ALI1, adhesion molecule with Ig-like domain 2
Research Background	Bromodomain and extraterminal domain inhibitors (BETi) represent promising therapeutic agents for metastatic melanoma, yet their mechanism of action remains unclear. Here we interrogated the transcriptional effects of BETi and identified AMIGO2, a transmembrane molecule, as a BET target gene essential for melanoma cell survival. AMIGO2 is upregulated in melanoma cells and tissues compared to human melanocytes and nevi, and AMIGO2 silencing in melanoma cells induces G1/S arrest followed by apoptosis.

Chemical Properties

Molecular Weight

42 kDa (Predicted); 60-70 kDa (Reducing conditions due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.