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Anti-Phospho-AMPKα (Thr172) Antibody (3O988) is a Rabbit antibody targeting Phospho-AMPKα (Thr172). Anti-Phospho-AMPKα (Thr172) Antibody (3O988) can be used in WB.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
20 μL | $82 | 7-10 days | |
100 μL | $234 | 7-10 days |
Description | Anti-Phospho-AMPKα (Thr172) Antibody (3O988) is a Rabbit antibody targeting Phospho-AMPKα (Thr172). Anti-Phospho-AMPKα (Thr172) Antibody (3O988) can be used in WB. |
Alias | AMPKalpha, AMPKa1, AMPK1, AMPK alpha 1, AMPK |
Ig Type | Monoclonal Rabbit IgG |
Clone | 3O988 |
Reactivity | Human;
Predicted to React with:Species predicted to react based on 100% sequence homology: Mouse, Cynomolgus, Pig |
Verified Activity | Western blot analysis of extracts from Rat brain, untreated (line A); treated with λ-phosphatase (line B) using Phospho-AMPKα (Thr172) rabbit monoclonal Antibody at 1:2000 dilution. |
Application | WB |
Recommended Dose | WB: 1:2000-1:20000 |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the residues around (Thr172) of Human Phospho-AMPKα. |
Purification | Protein A |
Appearance | Liquid |
Formulation | 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5 |
Research Background | The PRKAA1 gene encodes the catalytic alpha-subunit of 5' AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor that maintains energy homeostasis within the cell and is activated when the AMP/ATP ratio increases. Moreover, AMPK has been shown to be involved in inhibiting tumour growth and metastasis, and has also been implicated in the pathology of neurodegenerative and cardiac disorders. All 5 tested tag SNPs of the PRKAA1 gene (rs13361707, rs154268, rs3805486, rs6882903, and rs10074991) were significantly associated with gastric cancer.An inhibitor of PRKAA1 promoted the secretion of IL6, whereas an agonist of PRKAA1 suppressed the production of IL6. |
Conjucates | Unconjugated |
Immunogen | A synthetic peptide corresponding to the residues around (Thr172) of Human Phospho-AMPKα |
Antigen Species | Human |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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