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OTUB2-IN-1
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Catalog No. T87947
OTUB2-IN-1 is a selective OTUB2 inhibitor with anti-tumor activity that inhibits the expression of PD-L1 protein in tumor cells and inhibits tumor growth, and can be used to study skin cancer and non-small cell lung cancer (NSCLC).
OTUB2-IN-1
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Purity: 98.19%
Catalog No. T87947
OTUB2-IN-1 is a selective OTUB2 inhibitor with anti-tumor activity that inhibits the expression of PD-L1 protein in tumor cells and inhibits tumor growth, and can be used to study skin cancer and non-small cell lung cancer (NSCLC).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | - | In Stock | |
| 5 mg | $483 | - | In Stock | |
| 10 mg | $692 | - | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,490 | - | In Stock | |
| 100 mg | $1,970 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.19%
Appearance:Solid
Color:Red
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | OTUB2-IN-1 is a selective OTUB2 inhibitor with anti-tumor activity that inhibits the expression of PD-L1 protein in tumor cells and inhibits tumor growth, and can be used to study skin cancer and non-small cell lung cancer (NSCLC). |
| In vitro | Incubation of recombinant GST-OTUB2 protein with OTUB2-IN-1 resulted in significant inhibition of Ub-R110 cleavage by GST-OTUB2 in a dose-dependent manner, suggesting that OTUB2-IN-1 can inhibit the hydrolytic activity of recombinant GST-OTUB2 protein toward its substrate Ub-R110 in vitro. [1] |
| In vivo | Evaluated the therapeutic potential of OTUB2-IN-1 using a mouse LL/2 tumor model. OTUB2-IN-1 treatment significantly suppressed tumor growth and prolonged mouse survival, and no obvious toxicity was observed. To clarify the effect of OTUB2-IN-1 in tumor inhibition through regulation of PD-L1 in vivo, LL/2 cells with stably expressed PD-L1 and control plasmids were used to establish a tumor model. As expected, in comparison to the control group, overexpressed PD-L1 resulted in a substantial increase in tumor growth, whereas OTUB2-IN-1 significantly reduced the PD-L1-overexpressing tumor growth. [1] |
| Molecular Weight | 434.49 |
| Formula | C19H18N2O6S2 |
| Smiles | O=C(O)CN(C(/C1=C2C(N(CCCCCC(O)=O)C(S\2)=S)=O)=O)C3=C1C=CC=C3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (92.06 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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