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Anti-NLRP3 Polyclonal Antibody 5
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Catalog No. TMAB-01247
Alias PYRIN-containing APAF1-like protein 1, PYPAF1, NLRP3, NALP3, NACHT, LRR and PYD domains-containing protein 3, LRR and PYD domains-containing protein 3, Cryopyrin, Cold-induced autoinflammatory syndrome 1 protein, CIAS1, Caterpiller protein 1.1 (CLR1.1), C1orf7, Angiotensin/vasopressin receptor AII/AVP-like
Anti-NLRP3 Polyclonal Antibody 5 is a Rabbit antibody targeting NLRP3. Anti-NLRP3 Polyclonal Antibody 5 can be used in WB.
Anti-NLRP3 Polyclonal Antibody 5
Anti-NLRP3 Polyclonal Antibody 5
😃Good
Catalog No. TMAB-01247Alias PYRIN-containing APAF1-like protein 1, PYPAF1, NLRP3, NALP3, NACHT, LRR and PYD domains-containing protein 3, LRR and PYD domains-containing protein 3, Cryopyrin, Cold-induced autoinflammatory syndrome 1 protein, CIAS1, Caterpiller protein 1.1 (CLR1.1), C1orf7, Angiotensin/vasopressin receptor AII/AVP-like
Anti-NLRP3 Polyclonal Antibody 5 is a Rabbit antibody targeting NLRP3. Anti-NLRP3 Polyclonal Antibody 5 can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-NLRP3 Polyclonal Antibody 5 is a Rabbit antibody targeting NLRP3. Anti-NLRP3 Polyclonal Antibody 5 can be used in WB. |
| Synonyms | PYRIN-containing APAF1-like protein 1, PYPAF1, NLRP3, NALP3, NACHT, LRR and PYD domains-containing protein 3, LRR and PYD domains-containing protein 3, Cryopyrin, Cold-induced autoinflammatory syndrome 1 protein, CIAS1, Caterpiller protein 1.1 (CLR1.1), C1orf7, Angiotensin/vasopressin receptor AII/AVP-like |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | THP-1 (H) cells were treated with or without LPS (10 µg/ml) for 8 h, 25 μg total protein per Lane of cell lysates probed with NLRP3 polyclonal antibody, unconjugated (TMAB-01247) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at RT for 60 min.  |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. |
| Tissue Specificity | Expressed in blood leukocytes. Strongly expressed in polymorphonuclear cells and osteoblasts. Undetectable or expressed at a lower magnitude in B- and T-lymphoblasts, respectively. High level of expression detected in chondrocytes. Detected in non-keratin |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. Subcellular Location : Cytoplasm. |
| Immunogen | Recombinant Protein: human NLRP3 |
| Antigen Species | Human |
| Gene Name | NLRP3 |
| Gene ID | |
| Protein Name | NACHT, LRR and PYD domains-containing protein 3 |
| Uniprot ID | |
| Biology Area | TNF,Inflammatory mediators,Macrophage / Inflamm.,NFkB Pathway |
| Function | May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. |
| Molecular Weight | Theoretical: 114 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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