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Anti-NLRP3 Polyclonal Antibody 5 is a Rabbit antibody targeting NLRP3. Anti-NLRP3 Polyclonal Antibody 5 can be used in WB.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $220 | 7-10 days | |
100 μL | $374 | 7-10 days | |
200 μL | $527 | 7-10 days |
Description | Anti-NLRP3 Polyclonal Antibody 5 is a Rabbit antibody targeting NLRP3. Anti-NLRP3 Polyclonal Antibody 5 can be used in WB. |
Alias | PYRIN-containing APAF1-like protein 1, PYPAF1, NLRP3, NALP3, NACHT, LRR and PYD domains-containing protein 3, LRR and PYD domains-containing protein 3, Cryopyrin, Cold-induced autoinflammatory syndrome 1 protein, CIAS1, Caterpiller protein 1.1 (CLR1.1), C1orf7, Angiotensin/vasopressin receptor AII/AVP-like |
Ig Type | IgG |
Reactivity | Human |
Verified Activity | THP-1 (H) cells were treated with or without LPS (10 µg/ml) for 8 h, 25 μg total protein per Lane of cell lysates probed with NLRP3 polyclonal antibody, unconjugated (TMAB-01247) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at RT for 60 min. |
Application | WB |
Recommended Dose | WB: 1:500-2000 |
Antibody Type | Polyclonal |
Host Species | Rabbit |
Subcellular Localization | Cytoplasm. |
Construction | Hybridoma Polyclonal Antibody |
Purification | Protein A purified |
Appearance | Liquid |
Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Research Background | May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. Subcellular Location : Cytoplasm. |
Immunogen | Recombinant Protein: human NLRP3 |
Antigen Species | Human |
Gene ID | |
Uniprot ID | |
Biology Area | TNF,Inflammatory mediators,Macrophage / Inflamm.,NFkB Pathway |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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