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2'-C-Methyladenosine

🥰Excellent
Catalog No. T60531Cas No. 15397-12-3

2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication and a ribonucleoside diphosphate reductase inhibitor from Corynebacterium renalis. It inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC50 values of 0.3 μM and 1.9 μM, respectively. Additionally, 2'-C-Methyladenosine inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis.

2'-C-Methyladenosine

2'-C-Methyladenosine

🥰Excellent
Purity: 98.31%
Catalog No. T60531Cas No. 15397-12-3
2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication and a ribonucleoside diphosphate reductase inhibitor from Corynebacterium renalis. It inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC50 values of 0.3 μM and 1.9 μM, respectively. Additionally, 2'-C-Methyladenosine inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis.
Pack SizePriceAvailabilityQuantity
5 mg$31In Stock
10 mg$45In Stock
25 mg$89In Stock
50 mg$147In Stock
100 mg$228In Stock
500 mg$573In Stock
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Batch Information

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Purity:98.31%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication and a ribonucleoside diphosphate reductase inhibitor from Corynebacterium renalis. It inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC50 values of 0.3 μM and 1.9 μM, respectively. Additionally, 2'-C-Methyladenosine inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis.
In vivo
2'-C-Methyladenosine inhibits the HCV replicon in HB110A cells with an IC50 value of 0.3 μM.[1]
2'-C-Methyladenosine inhibits NS5B-catalyzed RNA synthesis with an IC50 value of 1.9 μM.[1]
2'-C-Methyladenosine potently inhibits LRV1 in Leishmania Guyana (Lgy) and Leishmania braziliensis.[2]
Chemical Properties
Molecular Weight281.27
FormulaC11H15N5O4
Cas No.15397-12-3
SmilesC[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(N)ncnc12
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (213.32 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.5553 mL17.7765 mL35.5530 mL177.7651 mL
5 mM0.7111 mL3.5553 mL7.1106 mL35.5530 mL
10 mM0.3555 mL1.7777 mL3.5553 mL17.7765 mL
20 mM0.1778 mL0.8888 mL1.7777 mL8.8883 mL
50 mM0.0711 mL0.3555 mL0.7111 mL3.5553 mL
100 mM0.0356 mL0.1778 mL0.3555 mL1.7777 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

HCVProteaseHCV repliconHCV Protease
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