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NBD-556

Name: NBD-556
Brand: TargetMol
SKU: T16276
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16276Cas No. 333353-44-9

NBD-556 is a small molecule mimetic of CD4. NBD-556 recognizes the HIV-1 envelope protein gp120 and induces restructuring of gp120 analogous to CD4 binding.

NBD-556

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Purity: 99.79%

Catalog No. T16276Cas No. 333353-44-9

NBD-556 is a small molecule mimetic of CD4. NBD-556 recognizes the HIV-1 envelope protein gp120 and induces restructuring of gp120 analogous to CD4 binding.

Pack Size	Price	Availability
5 mg	$29	In Stock
10 mg	$48	In Stock
25 mg	$92	In Stock
50 mg	$143	In Stock
100 mg	$215	In Stock
200 mg	$317	In Stock
1 mL x 10 mM (in DMSO)	$32	In Stock

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Batch Information

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Purity:99.79%

Resource Download

COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description

NBD-556 is a small molecule mimetic of CD4. NBD-556 recognizes the HIV-1 envelope protein gp120 and induces restructuring of gp120 analogous to CD4 binding.

In vitro

HIV NBD-556 N-phenyl-N′-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamide analogs as a novel class of human immunodeficiency virus type 1 (HIV-1) entry inhibitors that block the gp120–CD4 interaction. The small molecule NBD-556 mimics CD4 by binding the gp120 exterior envelope glycoprotein, moderately inhibiting virus entry into CD4-expressing target cells, and enhancing CCR5 binding and virus entry into CCR5-expressing cells lacking CD4.

Chemical Properties

Molecular Weight	337.84
Formula	C₁₇H₂₄ClN₃O₂
Cas No.	333353-44-9
Smiles	CC1(C)CC(CC(C)(C)N1)NC(=O)C(=O)Nc1ccc(Cl)cc1
Relative Density.	1.20 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 33.33 mg/mL (98.66 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9600 mL	14.7999 mL	29.5998 mL	147.9991 mL
5 mM	0.5920 mL	2.9600 mL	5.9200 mL	29.5998 mL
10 mM	0.2960 mL	1.4800 mL	2.9600 mL	14.7999 mL
20 mM	0.1480 mL	0.7400 mL	1.4800 mL	7.4000 mL
50 mM	0.0592 mL	0.2960 mL	0.5920 mL	2.9600 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc