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KCC-07

🥰Excellent
Catalog No. T8554Cas No. 315702-75-1

KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling.

KCC-07

KCC-07

🥰Excellent
Purity: 99.01%
Catalog No. T8554Cas No. 315702-75-1
KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$32In StockIn Stock
5 mg$68In StockIn Stock
10 mg$120In StockIn Stock
25 mg$235In StockIn Stock
50 mg$373In StockIn Stock
100 mg$556In StockIn Stock
200 mg$792In StockIn Stock
1 mL x 10 mM (in DMSO)$71In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.01%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling.
In vitro
In vitro, KCC-07 treatment Medulloblastomas (MB) cells?clearly inhibited MB cell growth, consistent with induction of anti-proliferative BAI1/p53/p21 signaling
Cell Research
KCC-07?treatment?Medulloblastomas (MB) cells, Concentration with?10 μM and?Incubation Time with?72 hours
Chemical Properties
Molecular Weight269.32
FormulaC14H11N3OS
Cas No.315702-75-1
SmilesOC1=CC=CC(NC2=NC(=CS2)C2=NC=CC=C2)=C1
Relative Density.1.380 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 22.5 mg/mL (83.54 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.43 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.7131 mL18.5653 mL37.1306 mL185.6528 mL
5 mM0.7426 mL3.7131 mL7.4261 mL37.1306 mL
10 mM0.3713 mL1.8565 mL3.7131 mL18.5653 mL
20 mM0.1857 mL0.9283 mL1.8565 mL9.2826 mL
50 mM0.0743 mL0.3713 mL0.7426 mL3.7131 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

p53MBD2 (methyl-CpG-binding domain protein 2)MBD2KCC-07KCC07KCC 07InhibitorinhibitDNAAlkylatorDNA Alkylator/CrosslinkerDNA AlkylatorCrosslinkerbrain-penetrantBAI1anti-proliferativeanticancerADGRB1ADGR
Related Tags: buy KCC-07 | purchase KCC-07 | KCC-07 cost | order KCC-07 | KCC-07 chemical structure | KCC-07 in vitro | KCC-07 formula | KCC-07 molecular weight
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