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diABZI STING agonist-1 trihydrochloride

diABZI STING agonist-1 trihydrochloride
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diABZI STING agonist-1 trihydrochloride

Catalog No. T5516Cas No. 2138299-34-8
diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.
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Pack SizePriceAvailabilityQuantity
1 mg$175In Stock
5 mg$372In Stock
10 mg$619In Stock
25 mg$987In Stock
50 mg$1,370In Stock
100 mg$1,850In Stock
1 mL x 10 mM (in DMSO)$655In Stock
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Product Introduction

diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.
In vitro
Activation of diABZI STING agonist-1 trihydrochloride elicits a type-I interferon response that propagates interferon receptor signalling in tumour-resident dendritic cells and leads to antitumour CD8+ T cell responses in vivo.
Animal Research
To evaluate the potential therapeutic effects of systemically administered diABZI STING agonist-1 trihydrochloride, tested the efficacy of intravenously delivered diABZI STING in a syngeneic mouse model of colorectal tumours (CT-26) in BALB/c mice.?We first established the pharmacokinetic profile of STING in BALB/c mice following intravenous injection of 3 mg/kg .?STING exhibited systemic exposure with a half-life of 1.4 h and achieved systemic concentrations greater than the half-maximal effective concentration (EC50) for mouse STING (~200 ng/ml).?Next, we tested an intermittent dosing paradigm in which 1.5 mg/kg STING was injected intravenously on days 1, 4, and 8 in mice with approximately 100 mm^3 subcutaneous CT-26 tumours.?Treatment with STING resulted in significant tumour growth inhibition as measured by tumour volume AUC analysis (P<0.001), and significantly improved survival (P<0.001) with 8 out of 10 mice remaining tumour free at the end of the study on day 43.
Chemical Properties
Molecular Weight959.32
Cas No.2138299-34-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 125 mg/mL (130.30 mM)
Solution Preparation Table
1 mM1.0424 mL5.2120 mL10.4241 mL52.1203 mL
5 mM0.2085 mL1.0424 mL2.0848 mL10.4241 mL
10 mM0.1042 mL0.5212 mL1.0424 mL5.2120 mL
20 mM0.0521 mL0.2606 mL0.5212 mL2.6060 mL
50 mM0.0208 mL0.1042 mL0.2085 mL1.0424 mL
100 mM0.0104 mL0.0521 mL0.1042 mL0.5212 mL


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