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diABZI STING agonist-1 trihydrochloride

diABZI STING agonist-1 trihydrochloride
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Purity:98.76%
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diABZI STING agonist-1 trihydrochloride

Catalog No. T5516Cas No. 2138299-34-8
diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$175In Stock
5 mg$372In Stock
10 mg$619In Stock
25 mg$987In Stock
50 mg$1,370In Stock
100 mg$1,850In Stock
1 mL x 10 mM (in DMSO)$655In Stock
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Product Introduction

Bioactivity
Description
diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.
In vitro
Activation of diABZI STING agonist-1 trihydrochloride elicits a type-I interferon response that propagates interferon receptor signalling in tumour-resident dendritic cells and leads to antitumour CD8+ T cell responses in vivo.
Animal Research
To evaluate the potential therapeutic effects of systemically administered diABZI STING agonist-1 trihydrochloride, tested the efficacy of intravenously delivered diABZI STING in a syngeneic mouse model of colorectal tumours (CT-26) in BALB/c mice.?We first established the pharmacokinetic profile of STING in BALB/c mice following intravenous injection of 3 mg/kg .?STING exhibited systemic exposure with a half-life of 1.4 h and achieved systemic concentrations greater than the half-maximal effective concentration (EC50) for mouse STING (~200 ng/ml).?Next, we tested an intermittent dosing paradigm in which 1.5 mg/kg STING was injected intravenously on days 1, 4, and 8 in mice with approximately 100 mm^3 subcutaneous CT-26 tumours.?Treatment with STING resulted in significant tumour growth inhibition as measured by tumour volume AUC analysis (P<0.001), and significantly improved survival (P<0.001) with 8 out of 10 mice remaining tumour free at the end of the study on day 43.
Chemical Properties
Molecular Weight959.32
FormulaC42H54Cl3N13O7
Cas No.2138299-34-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 125 mg/mL (130.30 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.0424 mL5.2120 mL10.4241 mL52.1203 mL
5 mM0.2085 mL1.0424 mL2.0848 mL10.4241 mL
10 mM0.1042 mL0.5212 mL1.0424 mL5.2120 mL
20 mM0.0521 mL0.2606 mL0.5212 mL2.6060 mL
50 mM0.0208 mL0.1042 mL0.2085 mL1.0424 mL
100 mM0.0104 mL0.0521 mL0.1042 mL0.5212 mL

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