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diABZI STING agonist-1 trihydrochloride

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Catalog No. T5516Cas No. 2138299-34-8

diABZI STING agonist-1 (trihydrochloride) is a stimulator of interferon genes (STING) receptor agonist.

diABZI STING agonist-1 trihydrochloride
Other Forms of diABZI STING agonist-1 trihydrochloride:

diABZI STING agonist-1 trihydrochloride

🥰Excellent
Purity: 99.55%
Catalog No. T5516Cas No. 2138299-34-8
diABZI STING agonist-1 (trihydrochloride) is a stimulator of interferon genes (STING) receptor agonist.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$158In StockIn Stock
5 mg$335In StockIn Stock
10 mg$559In StockIn Stock
25 mg$891In StockIn Stock
50 mg$1,230In StockIn Stock
100 mg$1,660In StockIn Stock
1 mL x 10 mM (in DMSO)$591In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.55%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
diABZI STING agonist-1 (trihydrochloride) is a stimulator of interferon genes (STING) receptor agonist.
Targets&IC50
STING (mouse):200 ng /mL (EC50), STING (human):130 nM (EC50), H69AR cells:0.035 μM (EC50)
In vitro
diABZI STING agonist-1 trihydrochloride is a selective stimulator of interferon genes receptor (STING) agonist with EC50 values ​​of 130 and 186 nM in humans and mice.
In vivo
METHODS: diABZI STING agonist-1 (trihydrochloride) (3mg/kg, intravenous injection) was administered to BALB/c mice to observe the pharmacokinetic spectrum in the mice.
RESULTS diABZI STING agonist-1 (trihydrochloride) was systematically exposed, with a half-life of 1.4 h, and the systemic concentration was greater than the half-maximum effective concentration (EC50) of mouse STING (200 ng/ml). [1]
METHODS: diABZI STING agonist-1 (trihydrochloride) (1.5 mg/kg, 1, 4 and 8 days, intravenous injection) in mice with subcutaneous CT-26 tumors was analyzed by tumor volume AUC.
RESULTS diABZI STING agonist-1 (trihydrochloride) had a significant inhibitory effect on tumor growth and significantly improved survival rate (P<0.001). [1]
Animal Research
To evaluate the potential therapeutic effects of systemically administered diABZI STING agonist-1 trihydrochloride, tested the efficacy of intravenously delivered diABZI STING in a syngeneic mouse model of colorectal tumours (CT-26) in BALB/c mice.?We first established the pharmacokinetic profile of STING in BALB/c mice following intravenous injection of 3 mg/kg .?STING exhibited systemic exposure with a half-life of 1.4 h and achieved systemic concentrations greater than the half-maximal effective concentration (EC50) for mouse STING (~200 ng/ml).?Next, we tested an intermittent dosing paradigm in which 1.5 mg/kg STING was injected intravenously on days 1, 4, and 8 in mice with approximately 100 mm^3 subcutaneous CT-26 tumours.?Treatment with STING resulted in significant tumour growth inhibition as measured by tumour volume AUC analysis (P<0.001), and significantly improved survival (P<0.001) with 8 out of 10 mice remaining tumour free at the end of the study on day 43.
Chemical Properties
Molecular Weight959.32
FormulaC42H54Cl3N13O7
Cas No.2138299-34-8
SmilesCl.Cl.Cl.CCn1nc(C)cc1C(=O)Nc1nc2cc(cc(OC)c2n1C\C=C\Cn1c(NC(=O)c2cc(C)nn2CC)nc2cc(cc(OCCCN3CCOCC3)c12)C(N)=O)C(N)=O
Relative Density.no data available
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 5 mg/mL (5.21 mM), Sonication is recommended.
DMSO: 15 mg/mL (15.64 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.08 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.0424 mL5.2120 mL10.4241 mL52.1203 mL
5 mM0.2085 mL1.0424 mL2.0848 mL10.4241 mL
DMSO
1mg5mg10mg50mg
10 mM0.1042 mL0.5212 mL1.0424 mL5.2120 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

TMEM173STINGStimulator of Interferon GenesMPYSMITAInhibitorinhibitERISdiABZI STING agonist-1 TrihydrochloridediABZI STING agonist-1 trihydrochloridediABZI STING agonist1 trihydrochloridediABZI STING agonist-1diABZI STING agonist 1 trihydrochloride
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