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diABZI STING agonist-1 trihydrochloride
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Catalog No. T5516Cas No. 2138299-34-8
diABZI STING agonist-1 (trihydrochloride) is a stimulator of interferon genes (STING) receptor agonist.
diABZI STING agonist-1 trihydrochloride
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Purity: 99.55%
Catalog No. T5516Cas No. 2138299-34-8
diABZI STING agonist-1 (trihydrochloride) is a stimulator of interferon genes (STING) receptor agonist.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $158 | In Stock | In Stock | |
| 2 mg | $218 | In Stock | In Stock | |
| 5 mg | $335 | In Stock | In Stock | |
| 10 mg | $533 | In Stock | In Stock | |
| 25 mg | $786 | In Stock | In Stock | |
| 50 mg | $1,230 | - | In Stock | |
| 100 mg | $1,660 | - | In Stock | |
| 200 mg | $2,230 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $591 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.55%
Appearance:Solid
Color:White to Yellow
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Product Introduction
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| Description | diABZI STING agonist-1 (trihydrochloride) is a stimulator of interferon genes (STING) receptor agonist. |
| Targets&IC50 | STING (mouse):200 ng /mL (EC50), STING (human):130 nM (EC50), H69AR cells:0.035 μM (EC50) |
| In vitro | diABZI STING agonist-1 trihydrochloride is a selective stimulator of interferon genes receptor (STING) agonist with EC50 values of 130 and 186 nM in humans and mice. |
| In vivo | METHODS: diABZI STING agonist-1 (trihydrochloride) (3mg/kg, intravenous injection) was administered to BALB/c mice to observe the pharmacokinetic spectrum in the mice. RESULTS diABZI STING agonist-1 (trihydrochloride) was systematically exposed, with a half-life of 1.4 h, and the systemic concentration was greater than the half-maximum effective concentration (EC50) of mouse STING (200 ng/ml). [1] METHODS: diABZI STING agonist-1 (trihydrochloride) (1.5 mg/kg, 1, 4 and 8 days, intravenous injection) in mice with subcutaneous CT-26 tumors was analyzed by tumor volume AUC. RESULTS diABZI STING agonist-1 (trihydrochloride) had a significant inhibitory effect on tumor growth and significantly improved survival rate (P<0.001). [1] |
| Animal Research | To evaluate the potential therapeutic effects of systemically administered diABZI STING agonist-1 trihydrochloride, tested the efficacy of intravenously delivered diABZI STING in a syngeneic mouse model of colorectal tumours (CT-26) in BALB/c mice.?We first established the pharmacokinetic profile of STING in BALB/c mice following intravenous injection of 3 mg/kg .?STING exhibited systemic exposure with a half-life of 1.4 h and achieved systemic concentrations greater than the half-maximal effective concentration (EC50) for mouse STING (~200 ng/ml).?Next, we tested an intermittent dosing paradigm in which 1.5 mg/kg STING was injected intravenously on days 1, 4, and 8 in mice with approximately 100 mm^3 subcutaneous CT-26 tumours.?Treatment with STING resulted in significant tumour growth inhibition as measured by tumour volume AUC analysis (P<0.001), and significantly improved survival (P<0.001) with 8 out of 10 mice remaining tumour free at the end of the study on day 43. |
| Molecular Weight | 959.32 |
| Formula | C42H54Cl3N13O7 |
| Cas No. | 2138299-34-8 |
| Smiles | Cl.Cl.Cl.CCn1nc(C)cc1C(=O)Nc1nc2cc(cc(OC)c2n1C\C=C\Cn1c(NC(=O)c2cc(C)nn2CC)nc2cc(cc(OCCCN3CCOCC3)c12)C(N)=O)C(N)=O |
| Relative Density. | no data available |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | H2O: 5 mg/mL (5.21 mM), Sonication is recommended.  DMSO: 15 mg/mL (15.64 mM), Sonication is recommended. | |||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.08 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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