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Diflubenzuron

Name: Diflubenzuron
Brand: TargetMol
SKU: T7088
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7088Cas No. 35367-38-5

Alias Larvakil, Dimilin, Difubenzuron, Difluron

Diflubenzuron (Larvakil) is a benzoyl-urea insecticide, found to be a potent inhibitor of melanosome synthesis in mouse melanoma cells. Diflubenzuron has also been shown to inhibit TCDD-induced CYP1A1 expression in HepG2 cells.

Diflubenzuron

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Purity: 99.96%

Catalog No. T7088Alias Larvakil, Dimilin, Difubenzuron, DifluronCas No. 35367-38-5

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$48	In Stock	In Stock
500 mg	$113	In Stock	In Stock
1 g	$166	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.96%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Diflubenzuron AI Summary

Diflubenzuron demonstrates a wide range of bioactivities, including significant antitumor, antiviral, insecticidal, and antifeedant properties. In vivo, it shows antitumor activity against 6C3HED lymphosarcoma with inhibition percentages of 6.0% and 33.0% at doses of 300 mg/kg and 1600 mg/kg respectively for 10 days. Additionally, it has an IC50 value of >20.0 ug/mL for inhibiting the growth of CCRF-CEM cells over 72 hours. The compound acts as an agonist for retinoid X receptor alpha, peroxisome proliferator-activated receptor gamma, Aryl hydrocarbon Receptor (AhR), and antioxidant response element (ARE) with Nrf2-dependent transcriptional activity. It also inhibits binding or entry into cells for Lassa Virus and Marburg Virus and exhibits antiviral activity against Foot and Mouth Disease Virus. In terms of insecticidal capabilities, Diflubenzuron exhibits potent activities against a variety of pests. It shows 100% mortality rates in Culex pipiens pallens mosquito larvae at 0.01 mg/L after 8 days and significant mortality in Mythimna separata (Oriental armyworm) larvae, with 100% mortality observed at 0.5 mg/L and 1 mg/L after 4 days. It is also effective against Chilo suppressalis larvae, inhibiting N-acetyl-[1-14C]glucosamine incorporation with an EC50 of 20.0 nM and inhibiting chitin synthesis with IC50 values of 19.05 nM and 20.42 nM. Moreover, Diflubenzuron effectively controls insect populations in agricultural settings, causing over 90% egg mortality in Spodoptera litura at 1 to 4 ppm and significant mortality in Plutella xylostella with an LC50 of 19.9 ug/mL in susceptible strains. However, it demonstrates reduced efficacy against fufenozide-resistant strains with a Resistance ratio of 17.2. Its toxicity is evident in Daphnia magna with an EC90 of 0.5 ppb. In summary, Diflubenzuron is highly effective as an antitumor agent, antiviral compound, and potent insecticide with varied applications across different pest species and settings..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Diflubenzuron (Larvakil) is a benzoyl-urea insecticide, found to be a potent inhibitor of melanosome synthesis in mouse melanoma cells. Diflubenzuron has also been shown to inhibit TCDD-induced CYP1A1 expression in HepG2 cells.
Synonyms	Larvakil, Dimilin, Difubenzuron, Difluron

Chemical Properties

Molecular Weight	310.68
Formula	C₁₄H₉ClF₂N₂O₂
Cas No.	35367-38-5
Smiles	Fc1cccc(F)c1C(=O)NC(=O)Nc1ccc(Cl)cc1
Relative Density.	1.4301 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble

DMSO: 50 mg/mL (160.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2187 mL	16.0937 mL	32.1875 mL	160.9373 mL
5 mM	0.6437 mL	3.2187 mL	6.4375 mL	32.1875 mL
10 mM	0.3219 mL	1.6094 mL	3.2187 mL	16.0937 mL
20 mM	0.1609 mL	0.8047 mL	1.6094 mL	8.0469 mL
50 mM	0.0644 mL	0.3219 mL	0.6437 mL	3.2187 mL
100 mM	0.0322 mL	0.1609 mL	0.3219 mL	1.6094 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc