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MRT-83

Name: MRT-83
Brand: TargetMol
SKU: T12109
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12109Cas No. 1263131-92-5

MRT-83 is a potent Smo antagonist.

MRT-83

🥰Excellent

Purity: 99.81%

Catalog No. T12109Cas No. 1263131-92-5

MRT-83 is a potent Smo antagonist.

Pack Size	Price	Availability
2 mg	$38	In Stock
5 mg	$58	In Stock
10 mg	$93	In Stock
25 mg	$193	In Stock
50 mg	$333	In Stock
100 mg	$470	In Stock
200 mg	$662	In Stock
1 mL x 10 mM (in DMSO)	$68	In Stock

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Batch Information

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Purity:99.81%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	MRT-83 is a potent Smo antagonist.
In vitro	MRT-83 blocks BC binding to HEK-hSmo cells in a dose-dependent manner with an IC50 of 4.6 nM. MRT-83 abrogates BC binding to cells expressing mouse Smo with an IC50 of 14 nM, which is in good correlation with its IC50 in the Shh-light2 and alkaline phosphatase assays[1].
In vivo	MRT-83 can't up-regulation of Ptc transcription in the SVZ of these animals in agreement with complete inhibition of ShhN-mediated effects (8.7±2.4 Ptc+ cells/section, n=9) and is not different from vehicle-mediated effects[1].

Chemical Properties

Molecular Weight	538.59
Formula	C₃₁H₃₀N₄O₅
Cas No.	1263131-92-5
Smiles	COc1cc(cc(OC)c1OC)C(=O)NC(=N)Nc1ccc(C)c(NC(=O)c2ccc(cc2)-c2ccccc2)c1
Relative Density.	1.22 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (102.12 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8567 mL	9.2835 mL	18.5670 mL	92.8350 mL
5 mM	0.3713 mL	1.8567 mL	3.7134 mL	18.5670 mL
10 mM	0.1857 mL	0.9283 mL	1.8567 mL	9.2835 mL
20 mM	0.0928 mL	0.4642 mL	0.9283 mL	4.6417 mL
50 mM	0.0371 mL	0.1857 mL	0.3713 mL	1.8567 mL
100 mM	0.0186 mL	0.0928 mL	0.1857 mL	0.9283 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc