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JZP-430

Name: JZP-430
Brand: TargetMol
SKU: T15635
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T15635Cas No. 1672691-74-5

JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).

JZP-430

🥰Excellent

Purity: 99.78%

Catalog No. T15635Cas No. 1672691-74-5

Pack Size	Price	Availability
1 mg	$41	In Stock
5 mg	$68	In Stock
10 mg	$111	In Stock
25 mg	$201	In Stock
50 mg	$289	In Stock
100 mg	$413	In Stock
200 mg	$548	In Stock
1 mL x 10 mM (in DMSO)	$75	In Stock

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Batch Information

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Purity:99.78%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).
Targets&IC50	ABHD6:44 nM(Human)

Chemical Properties

Molecular Weight	354.47
Formula	C₁₆H₂₆N₄O₃S
Cas No.	1672691-74-5
Smiles	CN(C1CCCCCCC1)C(=O)Oc1nsnc1N1CCOCC1
Relative Density.	1.26 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (253.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8211 mL	14.1056 mL	28.2111 mL	141.0557 mL
5 mM	0.5642 mL	2.8211 mL	5.6422 mL	28.2111 mL
10 mM	0.2821 mL	1.4106 mL	2.8211 mL	14.1056 mL
20 mM	0.1411 mL	0.7053 mL	1.4106 mL	7.0528 mL
50 mM	0.0564 mL	0.2821 mL	0.5642 mL	2.8211 mL
100 mM	0.0282 mL	0.1411 mL	0.2821 mL	1.4106 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc