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JZP-430

Name: JZP-430
Brand: TargetMol
SKU: T15635
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15635Cas No. 1672691-74-5

JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).

JZP-430

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Purity: 99.78%

Catalog No. T15635Cas No. 1672691-74-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$111	In Stock	In Stock
25 mg	$201	In Stock	In Stock
50 mg	$289	In Stock	In Stock
100 mg	$413	In Stock	In Stock
200 mg	$548	-	In Stock
1 mL x 10 mM (in DMSO)	$75	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.78%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

JZP-430 AI Summary

JZP-430 exhibits bioactivities related to the inhibition of enzymes FAAH and ABHD6. It specifically inhibits human FAAH and ABHD6 enzymes at various concentrations and incubation times, resulting in reductions in glycerol production from the hydrolysis of 1-AG and 2-AG substrates. The compound demonstrates IC50 values ranging from 43.65 nM to 93.33 nM for the inhibition of ABHD6, indicating a potent inhibitory effect on this enzyme..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).
Targets&IC50	ABHD6:44 nM(Human)

Chemical Properties

Molecular Weight	354.47
Formula	C₁₆H₂₆N₄O₃S
Cas No.	1672691-74-5
Smiles	CN(C1CCCCCCC1)C(=O)Oc1nsnc1N1CCOCC1
Relative Density.	1.26 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (253.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8211 mL	14.1056 mL	28.2111 mL	141.0557 mL
5 mM	0.5642 mL	2.8211 mL	5.6422 mL	28.2111 mL
10 mM	0.2821 mL	1.4106 mL	2.8211 mL	14.1056 mL
20 mM	0.1411 mL	0.7053 mL	1.4106 mL	7.0528 mL
50 mM	0.0564 mL	0.2821 mL	0.5642 mL	2.8211 mL
100 mM	0.0282 mL	0.1411 mL	0.2821 mL	1.4106 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc