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PKM

Pyruvate kinase isozymes M1/M2 (PKM1/M2), also known as pyruvate kinase muscle isozyme (PKM), pyruvate kinase type K, cytosolic thyroid hormone-binding protein (CTHBP), thyroid hormone-binding protein 1 (THBP1), or opa-interacting protein 3 (OIP3), is an enzyme that in humans is encoded by the PKM2 gene.PKM2 is an isoenzyme of the glycolytic enzyme pyruvate kinase. Depending upon the different metabolic functions of the tissues, different isoenzymes of pyruvate kinase are expressed. PKM2 is expressed in some differentiated tissues, such as lung, fat tissue, retina, and pancreatic islets, as well as in all cells with a high rate of nucleic acid synthesis, such as normal proliferating cells, embryonic cells, and especially tumor cells.

  • Disodium monofluorophosphate
    T074510163-15-2
    Disodium monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase, which also irreversibly inhibits phosphorylase phosphatase.
    • $29
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  • PKM2 inhibitor G
    T67900904457-46-1
    PKM2 inhibitor G is a inhibitor of pyruvate kinase.
    • $195
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  • Dimethylaminomicheliolide HCl
    T60102L1403357-80-1
    Dimethylaminomicheliolide HCl has potential anti-inflammatory and anti-tumor activity and inhibits the proliferation of glioblastoma cells by targeting pyruvate kinase 2 (PKM2) and reconnecting aerobic cell populations.
    • $195
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  • Shikonin
    T1125517-89-5
    Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and selective PKM2 inhibitor. Shikonin exhibits antitumor, anti-inflammatory and wound healing activities.
    • $29
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    TargetMol | Citations Cited
  • PKM2-IN-1
    T417094164-88-2
    PKM2-IN-1 (compound 3k) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
    • $34
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  • DASA-58
    T68161203494-49-8
    DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
    • $37
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    TargetMol | Citations Cited
  • TEPP-46
    T72141221186-53-3
    TEPP-46 (ML265) is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in a mouse xenograft model. .
    • $41
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  • PKR-IN-2
    T124991628428-01-2
    PKR-IN-2 is a activator of pyruvate kinase (PKR).
    • $123
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    TargetMol | Inhibitor Sale
  • PKM2 activator 5
    T72693796092-26-7
    PKM2 activator 5 is a novel and potent PKM2 activator (AC50: 0.316 µM) with potential anticancer activity for the study of cancer metabolism-related diseases.
    • $47
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  • PKM2 activator 2
    T627581186660-06-9
    PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates the Warburg effect by normalizing cellular glycolytic metabolism through activation of PKM2.
    • $51
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  • DL-Serine
    T8363302-84-1
    DL-Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.
    • $48
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  • Mitapivat
    T42231260075-17-9
    Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.
    • $34
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