PKM (Inhibitors Agonists Modulators Antagonists)

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Metabolism

Acetyl-CoA Carboxylase

Amino Acids and Derivatives

Angiotensin-converting Enzyme (ACE)

Cholesterol synthesis

Endogenous Metabolite

Glutathione Peroxidase

(149)

Glyoxalase

(22)

HIF/HIF Prolyl-Hydroxylase

Indoleamine 2,3-Dioxygenase (IDO)

(117)

Isocitrate Dehydrogenase (IDH)

Mitochondrial Metabolism

(378)

N-Acetylglucosaminyltransferase

Procollagen C Proteinase

(2)

Prolyl Endopeptidase (PREP)

Reactive Oxygen Species

Serine/threonin kinase

(130)

Stearoyl-CoA Desaturase (SCD)

PKM

Pyruvate kinase isozymes M1/M2 (PKM1/M2), also known as pyruvate kinase muscle isozyme (PKM), pyruvate kinase type K, cytosolic thyroid hormone-binding protein (CTHBP), thyroid hormone-binding protein 1 (THBP1), or opa-interacting protein 3 (OIP3), is an enzyme that in humans is encoded by the PKM2 gene.PKM2 is an isoenzyme of the glycolytic enzyme pyruvate kinase. Depending upon the different metabolic functions of the tissues, different isoenzymes of pyruvate kinase are expressed. PKM2 is expressed in some differentiated tissues, such as lung, fat tissue, retina, and pancreatic islets, as well as in all cells with a high rate of nucleic acid synthesis, such as normal proliferating cells, embryonic cells, and especially tumor cells.

TEPP-46

ML265

T72141221186-53-3

TEPP-46 (ML265) is an activator of pyruvate kinase M2 (PKM2) (AC50=92 nM), selective for PKM1, PKL and PKR. TEPP-46 has antitumor activity.

PKM

36 €

In Stock

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Cited

Mitapivat

PKR-IN-1

T42231260075-17-9

Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.

PKM

30 €

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(+)-Shikonin

NSC 252844, Isoarnebin 4, C.I. 75535, Anchusa acid, Alkanna Red, (R)-(+)-Shikonin, (+)-Shikonin

T1125517-89-5

(+)-Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC₅₀=6.5 μM) and selective PKM2 inhibitor. (+)-Shikonin exhibits antitumor, anti-inflammatory and wound healing activities.

AIM2 Chloride channel HIV Protease NF-κB PKM TNF

26 €

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Cited

PKM2-IN-1

PKM2 inhibitor, compound 3k

T417094164-88-2

PKM2-IN-1 (compound 3k) exhibits inhibitory activity against PKM2 with an IC₅₀ of 2.95 μM, while the IC₅₀ for PKM1 is 4-5 times higher.

PKM

27 €

In Stock

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Cited

DASA-58

T68161203494-49-8

DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.

PKM

33 €

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Cited

PKR-IN-2

T124991628428-01-2

PKR-IN-2 is a activator of pyruvate kinase (PKR).

PKM

27 €

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Benserazide hydrochloride

Serazide, Ro 4-4602, Benserazide HCl

T151714919-77-8

Benserazide hydrochloride (Ro 4-4602) is a peripherally-acting L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.

Dopamine Receptor Others PKM

41 €

In Stock

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PKM2 inhibitor G

T67900904457-46-1

PKM2 inhibitor G is a inhibitor of pyruvate kinase.

PKM

105 €

In Stock

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DL-Serine

T8363302-84-1

DL-Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.

PKM TMV

27 €

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7-Hydroxyflavone

T74726665-86-7

7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2.with anti-inflammatory activity

Apoptosis COX Cytochromes P450 ERK Lipoxygenase Nrf2 PKM Virus Protease

27 €

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PKM2 activator 2

T627581186660-06-9

PKM2 activator 2, with an AC50 value of 66 nM, is a pyruvate kinase M2 (PKM2) activator that demonstrates anti-tumor proliferative properties and attenuates the Warburg effect by normalizing cellular glycolytic metabolism through the activation of PKM2.

PKM

46 €

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Disodium monofluorophosphate

NSC248

T074510163-15-2

Disodium monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase, which also irreversibly inhibits phosphorylase phosphatase.

Phosphatase Phosphorylase PKM

26 €

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Dimethylaminomicheliolide HCl

T60102L1403357-80-1

Dimethylaminomicheliolide HCl has potential anti-inflammatory and anti-tumor activity and inhibits the proliferation of glioblastoma cells by targeting pyruvate kinase 2 (PKM2) and reconnecting aerobic cell populations.

PKM

175 €

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Iminostilbene

Dibenzazepine

T0598256-96-2

Iminostilbene (Dibenzazepine) (Dibenzazepine) is a chemical precursor of carbamazepine which is used primarily in the treatment of epilepsy and neuropathic pain.

COX HIF/HIF Prolyl-Hydroxylase Interleukin NO Synthase Others PKM STAT TNF

26 €

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(Rac)-Etavopivat

(Rac)-FT-4202

T726632622070-93-1In house

(Rac)-Etavopivat ((Rac)-FT-4202), an isomer of Etavopivat, is an orally active erythrocyte pyruvate kinase-R (PKR) activator used in sickle cell disease and haemoglobinopathy research ^[1].

Others PKM

1.503 €

6-8 weeks

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PKM2-IN-3

T399842408841-19-8

PKM2-IN-3 is a potent PKM2 kinase inhibitor, displaying an IC₅₀ value of 4.1 μM. The compound effectively suppresses PKM2-mediated glycolysis and NLRP3 activation, thereby exerting an anti-neuroinflammatory effect.

Others PKM

873 €

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PF-06284674

T706651434288-24-0

PF-06284674 is a cell permeable, potent and selective M2 isoform of pyruvate kinase (PKM2) activator.

Others PKM

1.368 €

6-8 weeks

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PKM2 activator 5

T72693796092-26-7

PKM2 activator 5 is a novel and potent PKM2 activator (AC50: 0.316 µM) with potential anticancer activity for the study of cancer metabolism-related diseases.

PKM

42 €

6-8 weeks

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PKM2 activator 4

T72692781656-66-4

PKM2 Activator 4, a chemical compound, functions as an activator of PKM2 with an activation concentration (AC 50) ranging from 1 to 10 μM. It is primarily utilized in cancer research.

Others PKM

1.368 €

6-8 weeks

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NPD10084

T870331040706-91-9

NPD10084 is an inhibitor that targets the pyruvate kinase M2 subtype (PKM2). NPD10084 inhibits downstream signaling by interfering with protein-protein interactions between PKM2 and β-catenin or STAT3 through its action on the non-glucolytic signaling function of PKM2, thereby exhibiting antiproliferative activity against multiple colorectal cancer cell lines (in vitro IC₅₀ range: 0.8–1.9 μM).

PKM

31 €

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Mitapivat hydrochloride

AG-348 hydrochloride

T2061722559738-69-9

Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric activator of pyruvate kinase R (PK-R). It enhances the PK-R-catalyzed conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolysis pathway, increasing ATP production in red blood cells, and decreasing 2,3-diphosphoglycerate (2,3-DPG) levels. Mitapivat hydrochloride is being investigated for potential use in the study of pyruvate kinase deficiency and other anemia-related disorders.

PKM

Inquiry Price

10-14 weeks

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PKM2-IN-9

T204898498568-75-5

PKM2-IN-9 (compound C1) is a potent inhibitor of PKM2, demonstrating a 75% inhibition rate at 50 μM. It plays a significant role in cancer research.

PKM

1.503 €

8-10 weeks

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Vitamin K5 hydrochloride

T87621130-24-5

Vitamin K5 hydrochloride is a photosensitizer and antimicrobial agent that functions as a specific inhibitor of pyruvate kinase M2 (PKM2), with IC₅₀ values of 28 μM for PKM2, 191 μM for PKM1, and 120 μM for PKL. Vitamin K5 hydrochloride induces apoptosis in colon 26 cells, supporting its application in infection and cancer research as well as its practical use as a preservative in pharmaceutical, food, and beverage formulations.

PKM

27 €

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PKR Inhibitor, negative control

T209999852547-30-9

The PKR Inhibitor, negative control, is an inactive structural analog of RNA-dependent protein kinase (PKR) inhibitors, serving as a negative control. Additionally, it can inhibit LK-induced neuronal death, demonstrating significant neuroprotective properties.

PKM

Inquiry Price

10-14 weeks

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