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GSTO-IN-2

🥰Excellent
Catalog No. T11504Cas No. 1202710-57-3

GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50 values of 1.4 μM for GSTP1-1, 16.3 μM for GSTM1, and 3.6 μM for GSTA2.

GSTO-IN-2

GSTO-IN-2

🥰Excellent
Purity: 98%
Catalog No. T11504Cas No. 1202710-57-3
GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50 values of 1.4 μM for GSTP1-1, 16.3 μM for GSTM1, and 3.6 μM for GSTA2.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$599-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98%
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Product Introduction

Bioactivity
Description
GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50 values of 1.4 μM for GSTP1-1, 16.3 μM for GSTM1, and 3.6 μM for GSTA2.
Targets&IC50
GSTM1:16.3 μM, GSTP1-1:1.4 μM , GSTM1:16.3 μM , GSTA2:3.6 μM, GSTP1-1:1.4 μM, GSTA2:3.6 μM
In vitro
When the concentration of GSTO-IN-2 was 50μM, the inhibition rate of cisplatin on MCF-7 and MDA-MB-231 cell viability reached 640 % and 270 %, respectively. GSTO-IN-2 ( 25 and 50 μM ) enhanced the inhibitory effect of thiotepa on the activity of MCF-7 and MDA-MB-231, with inhibition rates of 170-320 % and 180-270 %, respectively [1].
Chemical Properties
Molecular Weight620.77
FormulaC33H52N2O9
Cas No.1202710-57-3
SmilesC[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](OC([C@@H](NC(CC[C@@H](C(O)=O)N)=O)CC(O)=O)=O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(O)=O)C)[H])[H]
Relative Density.1.26 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (128.87 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6109 mL8.0545 mL16.1090 mL80.5451 mL
5 mM0.3222 mL1.6109 mL3.2218 mL16.1090 mL
10 mM0.1611 mL0.8055 mL1.6109 mL8.0545 mL
20 mM0.0805 mL0.4027 mL0.8055 mL4.0273 mL
50 mM0.0322 mL0.1611 mL0.3222 mL1.6109 mL
100 mM0.0161 mL0.0805 mL0.1611 mL0.8055 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

GSTP1-1GSTO-IN-2GSTOIN2GSTO IN 2GSTM1GSTA2GST
Related Tags: buy GSTO-IN-2 | purchase GSTO-IN-2 | GSTO-IN-2 cost | order GSTO-IN-2 | GSTO-IN-2 chemical structure | GSTO-IN-2 in vitro | GSTO-IN-2 formula | GSTO-IN-2 molecular weight
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