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GSTO-IN-2

Name: GSTO-IN-2
Brand: TargetMol
SKU: T11504
Price: 599 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11504Cas No. 1202710-57-3

GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50 values of 1.4 μM for GSTP1-1, 16.3 μM for GSTM1, and 3.6 μM for GSTA2.

GSTO-IN-2

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Purity: 98%

Catalog No. T11504Cas No. 1202710-57-3

GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50 values of 1.4 μM for GSTP1-1, 16.3 μM for GSTM1, and 3.6 μM for GSTA2.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$599	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98%

Appearance:Solid

Color:White

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COA HNMR

Product Introduction

Bioactivity

Description	GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50 values of 1.4 μM for GSTP1-1, 16.3 μM for GSTM1, and 3.6 μM for GSTA2.
Targets&IC50	GSTM1:16.3 μM , GSTM1:16.3 μM, GSTP1-1:1.4 μM , GSTP1-1:1.4 μM, GSTA2:3.6 μM , GSTA2:3.6 μM
In vitro	When the concentration of GSTO-IN-2 was 50μM, the inhibition rate of cisplatin on MCF-7 and MDA-MB-231 cell viability reached 640 % and 270 %, respectively. GSTO-IN-2 ( 25 and 50 μM ) enhanced the inhibitory effect of thiotepa on the activity of MCF-7 and MDA-MB-231, with inhibition rates of 170-320 % and 180-270 %, respectively [1].

Chemical Properties

Molecular Weight	620.77
Formula	C₃₃H₅₂N₂O₉
Cas No.	1202710-57-3
Smiles	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](OC([C@@H](NC(CC[C@@H](C(O)=O)N)=O)CC(O)=O)=O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(O)=O)C)[H])[H]
Relative Density.	1.26 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (128.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6109 mL	8.0545 mL	16.1090 mL	80.5451 mL
5 mM	0.3222 mL	1.6109 mL	3.2218 mL	16.1090 mL
10 mM	0.1611 mL	0.8055 mL	1.6109 mL	8.0545 mL
20 mM	0.0805 mL	0.4027 mL	0.8055 mL	4.0273 mL
50 mM	0.0322 mL	0.1611 mL	0.3222 mL	1.6109 mL
100 mM	0.0161 mL	0.0805 mL	0.1611 mL	0.8055 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc