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Dup-721

Name: Dup-721
Brand: TargetMol
SKU: T38359
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38359Cas No. 104421-21-8

DuP-721 is a broad-spectrum, orally active antibacterial agent that inhibits a variety of clinically susceptible and resistant bacteria, particularly [M. tuberculosis].

Dup-721

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Purity: 99.84%

Catalog No. T38359Cas No. 104421-21-8

DuP-721 is a broad-spectrum, orally active antibacterial agent that inhibits a variety of clinically susceptible and resistant bacteria, particularly [M. tuberculosis].

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
2 mg	$46	In Stock	In Stock
5 mg	$77	In Stock	In Stock
10 mg	$128	In Stock	In Stock
25 mg	$263	In Stock	In Stock
50 mg	$389	In Stock	In Stock
100 mg	$556	In Stock	In Stock
200 mg	$758	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$86	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.84%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	DuP-721 is a broad-spectrum, orally active antibacterial agent that inhibits a variety of clinically susceptible and resistant bacteria, particularly [M. tuberculosis].
In vitro	DuP-721 (1.5-4 μg/ml) effectively inhibits both conventional antituberculosis drug-susceptible and -resistant Mycobacterium tuberculosis strains without showing cross-resistance to any tested anti-tuberculosis drugs[1]. It is ineffective against M. avium and M. intracellulare up to 250 μg/ml, but inhibits M. gordonoe and M. fortuitum at 3.9 μg/ml, and M. kansasii and M. scrofulaceum at 1.95 μg/ml and 15.6 μg/ml, respectively[1].
In vivo	DuP-721, the first oxazolidinone showed good activity against M. tuberculosis when given orally or parenterally to experimental animals. DuP-721 (oral gavage; 50-160 mg/kg) is protective against M. tuberculosis infection in mice. DuP-721 protects 100% of the infected animals at 50 mg/kg p.o. dose when administered daily for 17 days, and the same effect is observed at 160 mg/kg dose when the drug is administered only on day 11 and 12 post infection[1].

Chemical Properties

Molecular Weight	276.29
Formula	C₁₄H₁₆N₂O₄
Cas No.	104421-21-8
Smiles	CC(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)C(C)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (361.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (14.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6194 mL	18.0969 mL	36.1939 mL	180.9693 mL
5 mM	0.7239 mL	3.6194 mL	7.2388 mL	36.1939 mL
10 mM	0.3619 mL	1.8097 mL	3.6194 mL	18.0969 mL
20 mM	0.1810 mL	0.9048 mL	1.8097 mL	9.0485 mL
50 mM	0.0724 mL	0.3619 mL	0.7239 mL	3.6194 mL
100 mM	0.0362 mL	0.1810 mL	0.3619 mL	1.8097 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc