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Quinidine hydrochloride monohydrate
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Catalog No. T0266Cas No. 6151-40-2
Quinidine hydrochloride monohydrate is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and decreases automaticity. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
Quinidine hydrochloride monohydrate
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Purity: 99.68%
Catalog No. T0266Cas No. 6151-40-2
Quinidine hydrochloride monohydrate is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and decreases automaticity. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 mg | $33 | In Stock | In Stock | |
| 100 mg | $47 | In Stock | In Stock | |
| 500 mg | $112 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.68%
Appearance:solid
Color:White
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Product Introduction
Quinidine hydrochloride monohydrate AI Summary
Quinidine hydrochloride monohydrate demonstrates a diverse range of bioactivities. It exhibits potent inhibitory action against AmpC Beta-Lactamase with a potency of 5011.9 nM and shows inhibition of Chronic Active B-Cell Receptor Signaling at 29092.9 nM. The compound is highly effective against the malarial parasite plastid, with potencies varying between 3.7 nM and 177.8 nM across different assays and incubation times. Additionally, it induces DNA re-replication in MCF 10a normal breast cells with a potency of 29092.9 nM and inhibits Hepatitis C Virus (HCV) at 3162.3 nM. As a GLP-1 Receptor Inverse Agonist, it demonstrates a potency of 11220.2 nM, and it inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) with potencies of 25929.0 nM and 23109.3 nM in the absence and presence of CPT, respectively. The compound also inhibits USP1/UAF1 with a potency of 35481.3 nM.
In antiviral studies against SARS-CoV-2 (strain BavPat1) in Vero E6 cells, Quinidine hydrochloride monohydrate shows promising results, with an inhibition index of 1.411 compared to the arbidol control, indicating higher activity. It effectively inhibits viral RNA replication, achieving an EC50 value of 5110.0 nM. The compound has a selectivity index greater than 7.8, suggesting a favorable therapeutic window, and its cytotoxicity is low, with a CC50 value exceeding 40000.0 nM. These characteristics make Quinidine hydrochloride monohydrate a promising candidate for further antiviral research and development..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Quinidine hydrochloride monohydrate is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and decreases automaticity. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission. |
| Targets&IC50 | K+ channel:19.9 μM |
| Molecular Weight | 378.89 |
| Formula | C20H27ClN2O3 |
| Cas No. | 6151-40-2 |
| Smiles | O.Cl.[H][C@@]1(C[C@@H]2CCN1C[C@@H]2C=C)[C@@H](O)c1ccnc2ccc(OC)cc12 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 32.5 mg/mL (85.78 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.28 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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