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NSI189

Name: NSI189
Brand: TargetMol
SKU: T1833
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1833Cas No. 1270138-40-3

Alias NSI-189, NSI 189

NSI189 (NSI-189) is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine.

NSI189

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Purity: 99.72%

Catalog No. T1833Alias NSI-189, NSI 189Cas No. 1270138-40-3

NSI189 (NSI-189) is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$60	In Stock	In Stock
50 mg	$96	In Stock	In Stock
100 mg	$156	In Stock	In Stock
200 mg	$232	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.72%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

NSI189 AI Summary

NSI189 exhibits antiviral activity against SARS-CoV-2, as well as inhibitory effects on human HDAC6 enzyme. Specifically, it inhibits cytotoxicity of Caco-2 and VERO-6 cells at a concentration of 10 µM after 48 hours, with inhibition rates of 8.05% and -0.14%, respectively. Additionally, NSI189 demonstrates a 17.02% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM. Regarding its activity against the human HDAC6 enzyme, the compound shows 32.62% inhibition using a commercial peptide substrate and 5.15% inhibition with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	NSI189 (NSI-189) is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine.
Synonyms	NSI-189, NSI 189

Chemical Properties

Molecular Weight	366.5
Formula	C₂₂H₃₀N₄O
Cas No.	1270138-40-3
Smiles	CC(C)CCNc1ncccc1C(=O)N1CCN(Cc2ccccc2)CC1
Relative Density.	1.134 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (136.43 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7285 mL	13.6426 mL	27.2851 mL	136.4256 mL
5 mM	0.5457 mL	2.7285 mL	5.4570 mL	27.2851 mL
10 mM	0.2729 mL	1.3643 mL	2.7285 mL	13.6426 mL
20 mM	0.1364 mL	0.6821 mL	1.3643 mL	6.8213 mL
50 mM	0.0546 mL	0.2729 mL	0.5457 mL	2.7285 mL
100 mM	0.0273 mL	0.1364 mL	0.2729 mL	1.3643 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc