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23-Hydroxybetulinic acid

Name: 23-Hydroxybetulinic acid
Brand: TargetMol
SKU: T3S2152
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3S2152Cas No. 85999-40-2

Alias Anemosapogenin

23-Hydroxybetulinic acid (Anemosapogenin) shows potent anti-tumor effect in vivo, but it has some toxicity, structure modification should be needed.

23-Hydroxybetulinic acid

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Purity: 99.37%

Catalog No. T3S2152Alias AnemosapogeninCas No. 85999-40-2

23-Hydroxybetulinic acid (Anemosapogenin) shows potent anti-tumor effect in vivo, but it has some toxicity, structure modification should be needed.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$31	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$71	In Stock	In Stock
25 mg	$117	In Stock	In Stock
50 mg	$172	In Stock	In Stock
100 mg	$255	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.37%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

23-Hydroxybetulinic acid AI Summary

23-Hydroxybetulinic acid exhibits diverse bioactivities and antiproliferative effects against various human and mouse cancer cell lines, such as A549, BEL-7402, SF763, HepG2, A375, HeLa, and MCF7, with reported IC50 values ranging from 18680.0 nM to 104540.0 nM. It shows cytotoxicity in human M14 and L02 cells, and inhibitory effects on rabbit muscle glycogen phosphorylase A with IC50 values of approximately 16000.0 nM. Furthermore, 23-Hydroxybetulinic acid demonstrates antibacterial activity against Bacillus subtilis, Staphylococcus aureus, and community-associated methicillin-resistant Staphylococcus aureus USA300, with MIC values between 8.0 µg/mL and 16.0 µg/mL. In vivo, it inhibits tumor growth in xenografted ICR mice models, achieving tumor growth reductions ranging from 10.1% to 56.81%. Additionally, it shows inhibitory effects on carboxylesterase enzymes CES2A1 and CES1A1 in human liver microsomes, with IC50 values of 1900.0 nM and 100.0 nM respectively, and a preference for CES2A1. 23-Hydroxybetulinic acid also induces mitochondrial membrane potential loss in B16F10 cells in a dose-dependent manner and shows selective toxicity in NQO1-deficient and overexpressing HT-29 cells with a selectivity index of 1.06 and 1.36, respectively. Additionally, it exhibits limited inhibitory activity against human CD73..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	23-Hydroxybetulinic acid (Anemosapogenin) shows potent anti-tumor effect in vivo, but it has some toxicity, structure modification should be needed.
Synonyms	Anemosapogenin

Chemical Properties

Molecular Weight	472.70
Formula	C₃₀H₄₈O₄
Cas No.	85999-40-2
Smiles	[H][C@]12[C@@H](CC[C@@]1(CC[C@]1(C)[C@]2([H])CC[C@]2([H])[C@@]3(C)CC[C@H](O)[C@@](C)(CO)[C@]3([H])CC[C@@]12C)C(O)=O)C(C)=C
Relative Density.	1.106 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50.00 mg/mL (105.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (5.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1155 mL	10.5775 mL	21.1551 mL	105.7753 mL
5 mM	0.4231 mL	2.1155 mL	4.2310 mL	21.1551 mL
10 mM	0.2116 mL	1.0578 mL	2.1155 mL	10.5775 mL
20 mM	0.1058 mL	0.5289 mL	1.0578 mL	5.2888 mL
50 mM	0.0423 mL	0.2116 mL	0.4231 mL	2.1155 mL
100 mM	0.0212 mL	0.1058 mL	0.2116 mL	1.0578 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc