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Apoptosis inducer 44
Catalog No. T213169 Copy Product Info
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Apoptosis inducer44 is an apoptosis (apoptosis) inducer. It initiates MDA-MB-231 cell apoptosis by increasing Bax and Cyt C levels, reducing Bcl-2 levels, and activating caspase-3 cleavage. Additionally, Apoptosis inducer44 inhibits the invasion and migration of MDA-MB-231 cells by downregulating MMP-2 and MMP-9 expression and upregulating E-cadherin protein levels. Apoptosis inducer44 is applicable in breast cancer research.
Apoptosis inducer 44
Copy Product Info🥰Excellent
Catalog No. T213169
Apoptosis inducer44 is an apoptosis (apoptosis) inducer. It initiates MDA-MB-231 cell apoptosis by increasing Bax and Cyt C levels, reducing Bcl-2 levels, and activating caspase-3 cleavage. Additionally, Apoptosis inducer44 inhibits the invasion and migration of MDA-MB-231 cells by downregulating MMP-2 and MMP-9 expression and upregulating E-cadherin protein levels. Apoptosis inducer44 is applicable in breast cancer research.
Apoptosis inducer 44
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Apoptosis inducer44 is an apoptosis (apoptosis) inducer. It initiates MDA-MB-231 cell apoptosis by increasing Bax and Cyt C levels, reducing Bcl-2 levels, and activating caspase-3 cleavage. Additionally, Apoptosis inducer44 inhibits the invasion and migration of MDA-MB-231 cells by downregulating MMP-2 and MMP-9 expression and upregulating E-cadherin protein levels. Apoptosis inducer44 is applicable in breast cancer research. |
| In vitro | Apoptosis inducer 44 (Compound 19) exhibits cytotoxic activity against MDA-MB-231, MCF-7, 4T1, and Aml-12 cells with IC50 values of 4.13, 8.60, 39.95, and 31.60 μM, respectively. At concentrations of 10‑40 μM, it induces apoptosis in MDA-MB-231 cells via the mitochondrial pathway. Additionally, Apoptosis inducer 44 (5-40 μM) inhibits invasion and migration in MDA-MB-231 cells by downregulating MMP-2/MMP-9 expression and upregulating E-cadherin levels. |
| In vivo | Compound 19 (Apoptosis inducer 44) at a dosage of 20 mg/kg administered over 18 days significantly inhibits tumor growth of MDA-MB-231 cell xenografts in nude mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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