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p-Ethynylphenylalanine hydrochloride

🥰Excellent
Catalog No. T10142LCas No. 188640-63-3
Alias p-Ethynylphenylalanine hydrochloride(278605-15-5 free base), 4-Ethynyl-L-phenylalanine HCL

p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent, and specific inhibitor of TPH[1]. Its potential to selectively and reversibly inhibit serotonin biosynthesis may contribute to characterizing the role of serotonin in behavioral and physiological activities[1].

p-Ethynylphenylalanine hydrochloride
Other Forms of p-Ethynylphenylalanine hydrochloride:
p-EthynylphenylalanineT10142278605-15-5
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p-Ethynylphenylalanine hydrochloride

🥰Excellent
Purity: 99.03%
Catalog No. T10142LAlias p-Ethynylphenylalanine hydrochloride(278605-15-5 free base), 4-Ethynyl-L-phenylalanine HCLCas No. 188640-63-3
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent, and specific inhibitor of TPH[1]. Its potential to selectively and reversibly inhibit serotonin biosynthesis may contribute to characterizing the role of serotonin in behavioral and physiological activities[1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$30In Stock-
25 mg$45In Stock-
50 mg$64In Stock-
1 mL x 10 mM (in DMSO)$71In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.03%
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Product Introduction

Bioactivity
Description
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent, and specific inhibitor of TPH[1]. Its potential to selectively and reversibly inhibit serotonin biosynthesis may contribute to characterizing the role of serotonin in behavioral and physiological activities[1].
Targets&IC50
TPH:32.6 μM
In vitro
p-Ethynylphenylalanine hydrochloride was demonstrated to inhibit competitively and reversibly TPH in vitro (Ki = 32.6 +/- 6.2 microM vs. tryptophan)[1].
In vivo
Administration of p-Ethynylphenylalanine hydrochloride (30 mg/kg) to rats produced a 95 +/- 5% decrease in TPH activity in brain homogenates and a concomitant decrease in serotonin and 5-hydroxyindole-3-acetic acid levels (85%) at 24 h after injection[1].
Synonymsp-Ethynylphenylalanine hydrochloride(278605-15-5 free base), 4-Ethynyl-L-phenylalanine HCL
Chemical Properties
Molecular Weight225.67
FormulaC11H12ClNO2
Cas No.188640-63-3
SmilesCl.N[C@@H](Cc1ccc(cc1)C#C)C(O)=O
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 12 mg/mL (53.17 mM), Sonication is recommended.
DMSO: 99 mg/mL (438.69 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (14.62 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM4.4312 mL22.1562 mL44.3125 mL221.5625 mL
5 mM0.8862 mL4.4312 mL8.8625 mL44.3125 mL
10 mM0.4431 mL2.2156 mL4.4312 mL22.1562 mL
20 mM0.2216 mL1.1078 mL2.2156 mL11.0781 mL
50 mM0.0886 mL0.4431 mL0.8862 mL4.4312 mL
DMSO
1mg5mg10mg50mg
100 mM0.0443 mL0.2216 mL0.4431 mL2.2156 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Tryptophan HydroxylaseTryptophan hydroxylasetryptophanTPHserotoninp-Ethynylphenylalanine HydrochloridepEthynylphenylalanine hydrochloridep-Ethynylphenylalaninep Ethynylphenylalanine hydrochlorideInhibitorinhibithydroxylase5-HT5-HIAA
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