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Anti-L1CAM Antibody (5I245)
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Catalog No. TMAY-00333
Alias SPG1, S10, NCAM-L1, N-CAM-L1, N-CAML1, MIC5, MASA, L1 cell adhesion molecule, HSAS1, HSAS, CD171, CAML1
Anti-L1CAM Antibody (5I245) is a Mouse antibody targeting L1CAM. Anti-L1CAM Antibody (5I245) can be used in FCM.
Anti-L1CAM Antibody (5I245)
Anti-L1CAM Antibody (5I245)
😃Good
Catalog No. TMAY-00333Alias SPG1, S10, NCAM-L1, N-CAM-L1, N-CAML1, MIC5, MASA, L1 cell adhesion molecule, HSAS1, HSAS, CD171, CAML1
Anti-L1CAM Antibody (5I245) is a Mouse antibody targeting L1CAM. Anti-L1CAM Antibody (5I245) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: FCM Reactivity: Human |
| Alias | SPG1, S10, NCAM-L1, N-CAM-L1, N-CAML1, MIC5, MASA, L1 cell adhesion molecule, HSAS1, HSAS, CD171, CAML1 |
| Ig Type | Mouse IgG2a |
| Clone | 5I245 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of human CD171 expression on HeLa cells. Cells were stained with purified anti-Human CD171, then a FITC-conjugated second step antibody. The histogram were derived from events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD171 / N-CAML1 / L1CAM (rh CD171 / N-CAML1 / L1CAM; TMPY-01431; NP_000416.1; Met1-Glu1120). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | L1 cell adhesion molecule (L1CAM), also designated as CD171, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and a variety of cancer cells, including some common types of human cancer. L1CAM interacts with a variety of ligands including axonin-1, CD9, neurocan, and integrins, and it has been revealed that the RGD motif in the sixth Ig domain of L1CAM is a binding site for integrins, thus important for nuclear signaling. Disruption of L1CAM function causes three X-linked neurological syndromes, i.e. hydrocephalus, MASA syndrome (mental retardation, aphasia, shuffling gait, and adducted thumbs), and spastic paraplegia syndrome. Overexpression of L1CAM in normal and cancer cells increased motility, enhanced growth rate, and promoted cell transformation and tumorigenicity. Recent work has identified L1CAM (CD171) as a novel marker for human carcinoma progression, and a candidate for anti-cancer therapy. |
| Conjucates | Unconjugated |
| Others Formats | APC/PE |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Protein: Human CD171 / N-CAML1 / L1CAM protein (TMPY-01431) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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