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Ethambutol dihydrochloride

Name: Ethambutol dihydrochloride
Brand: TargetMol
SKU: T0810
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0810Cas No. 1070-11-7

Alias Ethambutol 2HCl, Emb dihydrochloride, CL40881

Ethambutol dihydrochloride is an anti-mycobacterial compound that inhibits arabinosyl transferase activity to prevent cell wall formation and can be used to induce hyperuricemia models.

Ethambutol dihydrochloride

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Purity: 99.95%

Catalog No. T0810Alias Ethambutol 2HCl, Emb dihydrochloride, CL40881Cas No. 1070-11-7

Ethambutol dihydrochloride is an anti-mycobacterial compound that inhibits arabinosyl transferase activity to prevent cell wall formation and can be used to induce hyperuricemia models.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$29	In Stock	In Stock
1 g	$42	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.95%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	Ethambutol dihydrochloride is an anti-mycobacterial compound that inhibits arabinosyl transferase activity to prevent cell wall formation and can be used to induce hyperuricemia models.
In vitro	Ethambutol primarily targets the product of the embB gene, inducing mutations within the emb gene in drug-resistant strains of tuberculosis. In Mycobacterium smegmatis, Ethambutol affects arabinogalactan and lipoarabinomannan biosynthesis.
In vivo	In animal models, Ethambutol is administered orally at a dosage of 100 mg/kg.
Synonyms	Ethambutol 2HCl, Emb dihydrochloride, CL40881

Chemical Properties

Molecular Weight	277.24
Formula	C₁₀H₂₆Cl₂N₂O₂
Cas No.	1070-11-7
Smiles	Cl.Cl.CC[C@H](CO)NCCN[C@H](CC)CO
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 60 mg/mL (216.42 mM), Sonication is recommended.

H2O: 51 mg/mL (183.96 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6070 mL	18.0349 mL	36.0698 mL	180.3492 mL
5 mM	0.7214 mL	3.6070 mL	7.2140 mL	36.0698 mL
10 mM	0.3607 mL	1.8035 mL	3.6070 mL	18.0349 mL
20 mM	0.1803 mL	0.9017 mL	1.8035 mL	9.0175 mL
50 mM	0.0721 mL	0.3607 mL	0.7214 mL	3.6070 mL
100 mM	0.0361 mL	0.1803 mL	0.3607 mL	1.8035 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc