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DDR1 Protein, Human, Recombinant (S496A, GST)
(Synonyms: TRKE, RTK6, PTK3A, NTRK4, NEP, MCK-10, HGK2, Epithelial discoidin domain-containing receptor 1, Epithelial discoidin domain receptor 1, EDDR1, DDR1, CD167a, CAK) Copy Product InfoSynonyms: TRKE, RTK6, PTK3A, NTRK4, NEP, MCK-10, HGK2, Epithelial discoidin domain-containing receptor 1, Epithelial discoidin domain receptor 1, EDDR1, DDR1, CD167a, CAK
Catalog No. TMPC-00201 Copy Product Info
DDR1 Protein, Human, Recombinant (S496A, GST) is expressed in Baculovirus-Insect Cells. The accession number is Q08345.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 μg | $1,350 | 35 days | 35 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | The specific activity of DDR1 (S496A) was determined to be 1.8 nmol /min/mg by radioactive kinase assay. |
| Description | DDR1 Protein, Human, Recombinant (S496A, GST) is expressed in Baculovirus-Insect Cells. The accession number is Q08345. |
| Species | Human |
| Expression System | Baculovirus-Insect Cells |
| Tag | N-GST |
| Accession Number | Q08345 |
| Construction | Recombinant human DDR1 (S496A) (444-end) protein was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
| Protein Purity | >75% as determined by SDS-PAGE.  |
| Formulation | Supplied as sterile 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products. |
| Synonyms | TRKE, RTK6, PTK3A, NTRK4, NEP, MCK-10, HGK2, Epithelial discoidin domain-containing receptor 1, Epithelial discoidin domain receptor 1, EDDR1, DDR1, CD167a, CAK |
| Research Background | Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK10/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK10/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway. |
| Molecular Weight | ~77 kDa |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: DDR1 Protein, Human, Recombinant (S496A, GST) chemical structure | DDR1 Protein, Human, Recombinant (S496A, GST) molecular weight
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