The specific activity of DDR1 (S496A) was determined to be 1.8 nmol /min/mg by radioactive kinase assay.

DDR1 Protein, Human, Recombinant (S496A, GST) is expressed in Baculovirus-Insect Cells. The accession number is Q08345.

Human

Baculovirus-Insect Cells

TRKE,RTK6,PTK3A,NTRK4,NEP,MCK-10,HGK2,Epithelial discoidin domain-containing receptor 1,Epithelial discoidin domain receptor 1,EDDR1,DDR1,CD167a,CAK

Recombinant human DDR1 (S496A) (444-end) protein was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

>75% as determined by SDS-PAGE.

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK10/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK10/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.